A0A2B4EIV3 · A0A2B4EIV3_9BACI

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    cobB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site26NAD+ (UniProtKB | ChEBI)
Binding site30NAD+ (UniProtKB | ChEBI)
Binding site37NAD+ (UniProtKB | ChEBI)
Binding site37nicotinamide (UniProtKB | ChEBI)
Binding site38NAD+ (UniProtKB | ChEBI)
Binding site105NAD+ (UniProtKB | ChEBI)
Binding site107NAD+ (UniProtKB | ChEBI)
Binding site107nicotinamide (UniProtKB | ChEBI)
Binding site108NAD+ (UniProtKB | ChEBI)
Binding site108nicotinamide (UniProtKB | ChEBI)
Active site123Proton acceptor
Binding site123NAD+ (UniProtKB | ChEBI)
Binding site131Zn2+ (UniProtKB | ChEBI)
Binding site134Zn2+ (UniProtKB | ChEBI)
Binding site151Zn2+ (UniProtKB | ChEBI)
Binding site154Zn2+ (UniProtKB | ChEBI)
Binding site190NAD+ (UniProtKB | ChEBI)
Binding site191NAD+ (UniProtKB | ChEBI)
Binding site216NAD+ (UniProtKB | ChEBI)
Binding site234NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      COL05_29295

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AFS059628
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0A2B4EIV3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-245Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class U subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    27,949
  • Last updated
    2017-12-20 v1
  • Checksum
    8B03C368420D49CD
MIFVQQFEEVRSILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQYKPNRGHRFLAEFEEQGKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKCKAGYDLQYMIDHEVPRCQKCNFILNPDVVLYGDTLPQYQNAITRLYETDVFIVMGTSLKVQPVASFPQIAKREIGATTILVNEESTGQEYNFDFVFQNKIGEFVEGLSSMK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NVEC01000117
EMBL· GenBank· DDBJ
PFV68725.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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