A0A2B4EIV3 · A0A2B4EIV3_9BACI
- ProteinNAD-dependent protein deacetylase
- GenecobB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids245 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity
- N6-acetyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 26 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 30 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 37 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 37 | nicotinamide (UniProtKB | ChEBI) | |||
Binding site | 38 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 105 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 107 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 107 | nicotinamide (UniProtKB | ChEBI) | |||
Binding site | 108 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 108 | nicotinamide (UniProtKB | ChEBI) | |||
Active site | 123 | Proton acceptor | |||
Binding site | 123 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 131 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 134 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 151 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 154 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 190 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 191 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 216 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 234 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent histone deacetylase activity | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein deacetylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus
Accessions
- Primary accessionA0A2B4EIV3
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length245
- Mass (Da)27,949
- Last updated2017-12-20 v1
- Checksum8B03C368420D49CD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NVEC01000117 EMBL· GenBank· DDBJ | PFV68725.1 EMBL· GenBank· DDBJ | Genomic DNA |