A0A2A8YLN2 · A0A2A8YLN2_BACAN
- ProteinCyclic-di-AMP phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids657 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).
Catalytic activity
- 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H+
Cofactor
Note: For phosphodiesterase activity, probably binds 2 Mn2+ per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 345 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 349 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 351 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 420 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 420 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 444 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 499 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleic acid binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclic-di-AMP phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus cereus group
Accessions
- Primary accessionA0A2A8YLN2
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 9-27 | Helical | ||||
Sequence: WFLYPVYVLAFFVFVLISI | ||||||
Transmembrane | 33-53 | Helical | ||||
Sequence: LMMGIISFFIFCIVLFVVVRF |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 173-301 | GGDEF | ||||
Sequence: QRTVLAVIYLDNYDEVTQGLDDQLRTNITSLVTSRLNEWAVKYGAYLKRASSERFFVVLNESILAQMEKGKFSILDQVREETSKRNIPLTLSVGVGSGDLPLSELGAMAQSGLDLALGRGGDQVAIKQA |
Sequence similarities
Belongs to the GdpP/PdeA phosphodiesterase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length657
- Mass (Da)74,292
- Last updated2020-10-07 v1
- ChecksumC8E7D7D77DBB61A8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017334 EMBL· GenBank· DDBJ | AAT34880.1 EMBL· GenBank· DDBJ | Genomic DNA |