A0A2A8DCT4 · A0A2A8DCT4_9LACT

  • Protein
    D-aminoacyl-tRNA deacylase
  • Gene
    dtd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionD-tyrosyl-tRNA(Tyr) deacylase activity
Molecular FunctionGly-tRNA(Ala) hydrolase activity
Molecular FunctionSer(Gly)-tRNA(Ala) hydrolase activity
Molecular FunctiontRNA binding
Biological ProcessD-amino acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-aminoacyl-tRNA deacylase
  • EC number
  • Short names
    DTD
  • Alternative names
    • Gly-tRNA(Ala) deacylase
      (EC:3.1.1.-
      ) . EC:3.1.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      dtd
    • ORF names
      B8W88_04930
      , D6120_05360
      , OGZ39_09640
      , OGZ51_02055

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 3
    • 581
    • OG2
    • L81-D1
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus

Accessions

  • Primary accession
    A0A2A8DCT4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif136-137Gly-cisPro motif, important for rejection of L-amino acids

Domain

A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.

Sequence similarities

Belongs to the DTD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    151
  • Mass (Da)
    16,532
  • Last updated
    2017-12-20 v1
  • Checksum
    1318BD19AC88A52B
MKIVIQRVKSASVSIDGVIKGKINQGFLLLVGVEDADSNFDLDYAVRKIAQMRIFSDEADKMNLSVQDIQGEILSISQFTLYAETKKGNRPSFSAAGKPDFAKAMYEKFNDSLAQIVPVKAGVFGADMQVELINDGPVTIILDTKEARKNA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAOWLP010000008
EMBL· GenBank· DDBJ
MDG4981920.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLY010000001
EMBL· GenBank· DDBJ
MDG4982933.1
EMBL· GenBank· DDBJ
Genomic DNA
NCWV01000005
EMBL· GenBank· DDBJ
PAK89267.1
EMBL· GenBank· DDBJ
Genomic DNA
RAGV01000007
EMBL· GenBank· DDBJ
RQE32536.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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