A0A2A7AKU3 · A0A2A7AKU3_9FIRM

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15ATP (UniProtKB | ChEBI)
Binding site25-29ADP (UniProtKB | ChEBI); allosteric activator; ligand shared between dimeric partners
Binding site76-77ATP (UniProtKB | ChEBI)
Binding site106-109ATP (UniProtKB | ChEBI)
Binding site107Mg2+ (UniProtKB | ChEBI); catalytic
Binding site129-131substrate; ligand shared between dimeric partners; in other chain
Active site131Proton acceptor
Binding site158ADP (UniProtKB | ChEBI); allosteric activator; ligand shared between dimeric partners; in other chain
Binding site166substrate; ligand shared between dimeric partners
Binding site173-175substrate; ligand shared between dimeric partners; in other chain
Binding site215ADP (UniProtKB | ChEBI); allosteric activator; ligand shared between dimeric partners; in other chain
Binding site218-220ADP (UniProtKB | ChEBI); allosteric activator; ligand shared between dimeric partners; in other chain
Binding site227substrate; ligand shared between dimeric partners; in other chain
Binding site248substrate; ligand shared between dimeric partners
Binding site254-257substrate; ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Cellular Component6-phosphofructokinase complex
Molecular Function6-phosphofructokinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionfructose-6-phosphate binding
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmonosaccharide binding
Biological Processcanonical glycolysis
Biological Processfructose 1,6-bisphosphate metabolic process
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      pfkA
    • ORF names
      CHR61_09375
      , CRH10_01000
      , DW905_04670
      , DWZ89_01550
      , GKD95_00500

Organism names

  • Taxonomic identifier
  • Strains
    • AHMP21
    • Indica
    • AF36-11AT
    • AM42-11AC
    • BIOML-A1
  • Taxonomic lineage
    Bacteria > Bacillati > Bacillota > Clostridia > Eubacteriales > Oscillospiraceae > Faecalibacterium

Accessions

  • Primary accession
    A0A2A7AKU3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-279Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    324
  • Mass (Da)
    35,005
  • Last updated
    2017-12-20 v1
  • MD5 Checksum
    EEF0EDBA6F85367DDB76B5FF13A39635
MEKQIKTIGVLTSGGDAPGMNAAVRAVVRAGLHKGFRMIGIQRGYNGLLDGECFEMNLRSVSNIISAGGTILYTARCLEFKTKEGQDKGAAKCRELGIDALVVIGGDGSYRGARELAHRGIPMIGLPGTIDNDIACTDYTIGYDTAMNTALEMIDKLRDTTQSHDRCSVVEVMGRNAGYIALNVAIASGAMAVLLPEKEFDMQHDILDKITETQRTGKRHFIVIVAEGIGHSQEIANEIQARTGIDTRATILGHVQRGGSPTLRDRVNASAMGYHAVCLLEQGKYNRIVGMKGEHLVDYPVDEALEMTKTLDPVLIDVCNTISI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023819
EMBL· GenBank· DDBJ
ATL88991.1
EMBL· GenBank· DDBJ
Genomic DNA
WKQN01000001
EMBL· GenBank· DDBJ
MSC61849.1
EMBL· GenBank· DDBJ
Genomic DNA
NOUW01000027
EMBL· GenBank· DDBJ
PDX89097.1
EMBL· GenBank· DDBJ
Genomic DNA
QVEQ01000001
EMBL· GenBank· DDBJ
RGB73500.1
EMBL· GenBank· DDBJ
Genomic DNA
QVEZ01000002
EMBL· GenBank· DDBJ
RGC06566.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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