Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A2A6CE31 · A0A2A6CE31_PRIPA

Function

function

Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.

Catalytic activity

  • (2E)-geranial + NADPH + O2 + H+ = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = pentyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = ethyl hexanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • sulcatone + NADPH + O2 + H+ = 4-methylpent-3-en-1-yl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • NADPH + O2 + H+ = H2O2 + NADP+
    This reaction proceeds in the forward direction.
    EC:1.6.3.1 (UniProtKB | ENZYME | Rhea)
  • heptan-2-one + NADPH + O2 + H+ = pentyl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • heptan-4-one + NADPH + O2 + H+ = propyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = propyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = ethyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNAD(P)H oxidase H2O2-forming activity
Molecular FunctionNADP binding
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase
  • EC number

Gene names

    • Name
      WBGene00281527

Organism names

  • Taxonomic identifier
  • Strain
    • PS312
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Diplogasteromorpha > Diplogasteroidea > Neodiplogasteridae > Pristionchus

Accessions

  • Primary accession
    A0A2A6CE31
  • Secondary accessions
    • A0A8R1Z0T2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Sequence similarities

Belongs to the FMO family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    540
  • Mass (Da)
    60,621
  • Last updated
    2017-12-20 v1
  • MD5 Checksum
    309514BDE67B710AE1E9DCE78E15C5B7
MEPTTSRRNICVVGAGAAGLPSIRHALLYGFNVVCYEAQSELGGLWRFNPEDTEYSCVMRSTVINTSKEFTAYSDFPPLPEEPNFMHNSRMLNYLKAYADHFKLTDHIQFEHKALSISRADKYDASGQWDVRVQNMKSSEITTTRFDGVLHCTGHHALPYSPALFPGQETFPGRVMHAHDYKDWRGFENQTIVVVGVGNSGCDIAVELSRVAKQVHLVSRRGTWVYNRIYNYGRPVDCTRYTRLNAAIKEVVPHSIAAASVRKQLNFRFDHELYGLKPKHDVMGAHPTINDELPNRIANGSIRVRPQINRFNGTTVHFEDGSMTEGVDTVILSTGYTVSFPEIESGELIKVDNNQVDLFQYVFPMCLPHDSLGIIGLIQPFGSIIPIAEMQARLVLAAIAGEDKMPVKTEREAIMSRKAAEMSKRYVQSRRHTVQVDYLPYMDELASLIGCDVPAWYTHLPHDQTMARLTLTAPHTAYFYRLSGPHAWDGAREAIMGIEERISRAFNSNHLKATAQSATKISPGLFLVIAAILFVLLVVS

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help