A0A2A5JY22 · NUCLP_PAELB

Function

function

Uptake of the purines adenine and guanine, and the pyrimidine uracil. Transport is probably proton-dependent.

Activity regulation

Inhibited by the proton gradient disruptor carbonyl cyanide m-chlorophenylhydrazone (CCCP), but not by the sodium gradient disruptor ouabain. Hypoxanthine, xanthine, cytosine and uric acid act as competitive inhibitors.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
7.04 μMadenine

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionxanthine transmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleobase transporter PlUacP

Gene names

    • ORF names
      PL1_3014

Organism names

Accessions

  • Primary accession
    A0A2A5JY22

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-29Helical
Transmembrane39-59Helical
Transmembrane63-83Helical
Transmembrane93-113Helical
Transmembrane118-138Helical
Transmembrane159-179Helical
Transmembrane181-201Helical
Transmembrane218-238Helical
Transmembrane306-326Helical
Transmembrane327-347Helical
Transmembrane365-385Helical
Transmembrane394-414Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004462371-434Nucleobase transporter PlUacP

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    45,792
  • Last updated
    2017-12-20 v1
  • Checksum
    5604C2CDD44CB9E8
MRKSKVLTLGFQHVLAMYAGAVIVPLIVGSSLKLNAEQLAYLVSIDLLTCGIATLLQVWRNKFFGIGLPVMLGCTFTAVGPMIAIGSEYGMPAIYGSVLASGLFLALFAGFFGKLARFFPPIVTGSVVTIIGITLIPVAVQDMGGGQGSADFGSLSNLALSFGVLLFIILANRFFTGFIRAISILLGLIFGTIAGAFMGKVDIGPLLDASWFHGIHPFYFGFPTFHLPSILTMTLVAIVSVMESTGVFVALGKITEKELTADDLKRGYRSEGLASILGSIMNSFPYTTYSQNVGLIQISKVKSRDVVITAGFILVILGFMPKIAALTLLIPTAVLGGAMIAMFGMVVSSGIKMLGAIDLNNHENLLIIACSVSVGLGVTVAPNLFDHLPDSIKILTSNGIVAGSLTAILMNFLFTVGRKKQDESHASAENVHAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADZY03000323
EMBL· GenBank· DDBJ
PCK69666.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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