A0A2A4Q5L3 · A0A2A4Q5L3_9BACT

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

158950100150200250300350400450500550
TypeIDPosition(s)Description
Binding site14-19GTP (UniProtKB | ChEBI)
Binding site126-129GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      COB80_02345

Organism names

Accessions

  • Primary accession
    A0A2A4Q5L3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-179Tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    589
  • Mass (Da)
    65,914
  • Last updated
    2017-12-20 v1
  • Checksum
    41BD136C19403227
MKNIRNFSIIAHIDHGKSTLADRMLEVTDTVADRKMRDQLLDKMDLERERGITIKMQPVRMQWGEYILNLIDTPGHIDFSYEVSRALKAVEGVVLLVDATQGIQAQTLSVLHLAREQGLTIIPVLSKVDSPLARVEDIQTELALLLEIDEEDILATSGKTGEGVSALLDAVVEKIPAPVAEVEELRALIFDFQYSDHRGIVLFVRVTDGSLKKGDKLKFSAAGEQFTALEIGIFTPEEESRDTLSAGEIGYIVTGIKKPGIVGVGDTVLGIRSQTSALAGYMEPRPVIWASVYPESQDDLALLRQSLERLRLMDSSLSYEEEASGIMGRGFRCGFLGMLHMEIVTXRLRREFSMEIVVTLPTTEYEITFKNGNVETIYTPTRFPNDGEAVGVREGWVEASILVPAEYVGNIMQLLHDHEAHVTGTETMPDGRTQMIAEMPLREMMRNFFDKLKNVSSGFASLAYEQIGKRDANVTRLDILIAEEIAPAFSRIVATRRLEEEAREMVGKLKEMLPKQLFVVKIQAKSQGRIIAGEKISAMRKDVTGYLYXGDITRKKKLLEKQKRGKKKALARGKVHIPHEVFMKVMRSE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NVSE01000019
EMBL· GenBank· DDBJ
PCH91546.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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