A0A2A4Q3R5 · A0A2A4Q3R5_9BACT

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • ORF names
      COB80_02985

Organism names

Accessions

  • Primary accession
    A0A2A4Q3R5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain41-189HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    25,087
  • Last updated
    2017-12-20 v1
  • Checksum
    864DB51B2E642CE7
MQKERKERMAQLTKALKRMYPEQKTELNYATQFQLVVAVMLSAQCTDKKVNECTQELFKKYKIPKDFAQANPVEFEKQISSVTFYRNKTKHVIAAAKLLVADFDGEVPQSISELILLPGVAYKTANVVLGELYGIWEGIATDTHVRRFALRFDLTDNKELTKISKGLEALVPKKDWRYINNGFVLYGRYICSARPHDCVEHTLTKIWPKAVNVWPKAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NVSE01000031
EMBL· GenBank· DDBJ
PCH91213.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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