A0A2A4JC83 · A0A2A4JC83_HELVI
- ProteinHedgehog protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids429 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Protein hedgehog N-product
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.
Protein hedgehog
The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Catalytic activity
- cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | morphogen activity | |
Molecular Function | patched binding | |
Molecular Function | peptidase activity | |
Molecular Function | transferase activity | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | cell fate specification | |
Biological Process | cell-cell signaling | |
Biological Process | intein-mediated protein splicing | |
Biological Process | protein autoprocessing | |
Biological Process | regulation of gene expression | |
Biological Process | segment polarity determination | |
Biological Process | smoothened signaling pathway | |
Biological Process | system development |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHedgehog protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Noctuoidea > Noctuidae > Heliothinae > Heliothis
Accessions
- Primary accessionA0A2A4JC83
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Lipid-anchor
Sonic hedgehog protein
Protein hedgehog N-product
Cell membrane ; Lipid-anchor
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-25 | Disordered | ||||
Sequence: MGGEQGMQAGHGGARRSDRAAAAGS | ||||||
Region | 83-112 | Disordered | ||||
Sequence: FGQHDPNISENKNTASGPPEGRITRDDDRF | ||||||
Compositional bias | 86-100 | Polar residues | ||||
Sequence: HDPNISENKNTASGP | ||||||
Domain | 234-334 | Hint | ||||
Sequence: AGCFPEGSKVYTENGPRDIATLRRGDKVLAASDNGKMVYSEVLTFIDRDPNTTRQFIEVTAENGVTITTTPSHLLLLAAADGWRESFASNIEVGDVLLTRG | ||||||
Domain | 336-380 | Hint | ||||
Sequence: ADVMRPSRVVKTRMLSKRGAYAPLTRTGTIIVDDVLASCYALVRS |
Sequence similarities
Belongs to the hedgehog family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length429
- Mass (Da)47,529
- Last updated2017-12-20 v1
- Checksum9946E7158590238F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 86-100 | Polar residues | ||||
Sequence: HDPNISENKNTASGP |
Keywords
- Technical term