A0A292ZE12 · A0A292ZE12_SPHSA

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit.

Features

Showing features for binding site.

116120406080100120140160
TypeIDPosition(s)Description
Binding site62[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site65[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site68[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site72[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site101[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site104[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site107[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site111[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioniron ion binding
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding
Biological Processaerobic respiration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit I
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit I
    • NDH-1 subunit I

Gene names

    • Name
      nuoI
    • ORF names
      H5V43_07455
      , SFOMI_1568

Organism names

Accessions

  • Primary accession
    A0A292ZE12

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain52-824Fe-4S ferredoxin-type
Domain92-1214Fe-4S ferredoxin-type

Sequence similarities

Belongs to the complex I 23 kDa subunit family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    161
  • Mass (Da)
    18,540
  • Last updated
    2017-12-20 v1
  • Checksum
    97101A06638C64D3
MSLGYYVKSFTLWEFVKAHALTLKYFFKPKATINYPYEKNPISPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIEAQPRDDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETREELIYDKAKLLENGDKWERAIAANLAADAPYR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BEWI01000031
EMBL· GenBank· DDBJ
GAY21035.1
EMBL· GenBank· DDBJ
Genomic DNA
CP060035
EMBL· GenBank· DDBJ
QOT72932.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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