A0A292ZAL8 · A0A292ZAL8_SPHSA

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site207-211GTP (UniProtKB | ChEBI)
Binding site212Zn2+ (UniProtKB | ChEBI); catalytic
Binding site223Zn2+ (UniProtKB | ChEBI); catalytic
Binding site225Zn2+ (UniProtKB | ChEBI); catalytic
Binding site228GTP (UniProtKB | ChEBI)
Binding site250-252GTP (UniProtKB | ChEBI)
Binding site272GTP (UniProtKB | ChEBI)
Active site284Proton acceptor
Active site286Nucleophile
Binding site307GTP (UniProtKB | ChEBI)
Binding site312GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionlyase activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA
    • ORF names
      H5V43_13850
      , SFOMI_1052

Organism names

Accessions

  • Primary accession
    A0A292ZAL8

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain166-328GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    37,318
  • Last updated
    2017-12-20 v1
  • MD5 Checksum
    5EF32ACB7E956E0B68820AA7FB4C40B4
MSARAAARAIDALRRGWPVRVQAADGAVRLMAVEGADAVTLAGFDPGAGADILISAARAQTLKLANQLAAADPDMPVLVARAPWIDVDVATAISDPVLDLASPLKGPFMAKPLAAPSAAKAALRLARLAGILPAYFVTAEGDSEAEVSAADIDAYDDAVHLAIATRARLPVSASETAEIVAFRSPDEPREHVALIVGQRDSSPPVIRLHSECLTGDVLGSLKCDCGPQLHQALHQIADSNWGILLYLRQEGRGIGLVNKLRAYALQDQGFDTVDANVRLGFAIDARDFSVAARMLDLLGVDEVRLLTNNPNKVTGLEAAGIRVAERLPIILPSNPHNERYLATKRDRTGHQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BEWI01000030
EMBL· GenBank· DDBJ
GAY20527.1
EMBL· GenBank· DDBJ
Genomic DNA
CP060035
EMBL· GenBank· DDBJ
QOT71167.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help