A0A292ZAL8 · A0A292ZAL8_SPHSA
- ProteinGTP cyclohydrolase-2
- GeneribA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids352 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Catalytic activity
- GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 207-211 | GTP (UniProtKB | ChEBI) | |||
Binding site | 212 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 223 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 225 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 228 | GTP (UniProtKB | ChEBI) | |||
Binding site | 250-252 | GTP (UniProtKB | ChEBI) | |||
Binding site | 272 | GTP (UniProtKB | ChEBI) | |||
Active site | 284 | Proton acceptor | |||
Active site | 286 | Nucleophile | |||
Binding site | 307 | GTP (UniProtKB | ChEBI) | |||
Binding site | 312 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | GTP binding | |
Molecular Function | GTP cyclohydrolase II activity | |
Molecular Function | lyase activity | |
Molecular Function | zinc ion binding | |
Biological Process | riboflavin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase-2
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingobium
Accessions
- Primary accessionA0A292ZAL8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)37,318
- Last updated2017-12-20 v1
- MD5 Checksum5EF32ACB7E956E0B68820AA7FB4C40B4
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BEWI01000030 EMBL· GenBank· DDBJ | GAY20527.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP060035 EMBL· GenBank· DDBJ | QOT71167.1 EMBL· GenBank· DDBJ | Genomic DNA |