A0A292ZAB9 · A0A292ZAB9_SPHSA

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site945-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site117-1255-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site121orotate (UniProtKB | ChEBI)
Binding site149orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      H5V43_15570
      , SFOMI_0285

Organism names

Accessions

  • Primary accession
    A0A292ZAB9

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-156Phosphoribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    20,774
  • Last updated
    2017-12-20 v1
  • Checksum
    91F9488D17EB5D15
MTDEEVLAEFRAAGALLEGHFILSSGRRSANYLQCARVLMNAERAGRLARATVQKLPRELRQEIDLVVSPAMGGLIIGHEIGRALDKDAVFLERPEGTFELRRGFAIAPGQKVLMVEDVVTTGLSSRQAIEAVEAEGGIVIAEAALVDRSAGEVELGVPFYPLVSINFPVYDADQVPPELAAIPAIKPGSRKQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BEWI01000030
EMBL· GenBank· DDBJ
GAY19764.1
EMBL· GenBank· DDBJ
Genomic DNA
CP060035
EMBL· GenBank· DDBJ
QOT71475.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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