A0A292Z2A6 · A0A292Z2A6_9PSEU
- ProteinNADH-quinone oxidoreductase subunit N
- GenenuoN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids539 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + 5 H+(in) + NADH = a quinol + 4 H+(out) + NAD+
CHEBI:132124 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = CHEBI:24646 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Molecular Function | quinone binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit N
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Pseudonocardia
Accessions
- Primary accessionA0A292Z2A6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-40 | Helical | ||||
Sequence: AYGAIAPVLIVLGGACVAVLV | ||||||
Transmembrane | 52-73 | Helical | ||||
Sequence: VQVALSLVILAAAGVTLGVHAG | ||||||
Transmembrane | 93-111 | Helical | ||||
Sequence: LFLWGTLLLLGLGSILLIA | ||||||
Transmembrane | 164-181 | Helical | ||||
Sequence: VFPFALFALGGMMTFVAA | ||||||
Transmembrane | 217-241 | Helical | ||||
Sequence: VKYFLLGAFASAFFLYGLALLYGYA | ||||||
Transmembrane | 261-280 | Helical | ||||
Sequence: TLLFGGLALLVVGLLFKGSV | ||||||
Transmembrane | 300-319 | Helical | ||||
Sequence: AFMAACTKVAAFGAISRVLF | ||||||
Transmembrane | 331-350 | Helical | ||||
Sequence: GVLWAVAIVSMVIGAVLGLT | ||||||
Transmembrane | 388-405 | Helical | ||||
Sequence: LLAYGFTTLAVFGVISLV | ||||||
Transmembrane | 426-446 | Helical | ||||
Sequence: PLLAGVMTFLLLALAGIPLTS | ||||||
Transmembrane | 466-490 | Helical | ||||
Sequence: LVIVALIASAVAAFFYLRVIVLMYF | ||||||
Transmembrane | 502-524 | Helical | ||||
Sequence: VPGAFTTAAITLGVLVTLLLGIV |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 133-155 | Disordered | ||||
Sequence: GGGGESVLPGIEAEDDRDYGEPG | ||||||
Domain | 181-474 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: ANDLLTMFIALEVLSLPLYLMCGLARRRRLLSQEAAVKYFLLGAFASAFFLYGLALLYGYAGSVKLSAIAQAAAGSDRSDTLLFGGLALLVVGLLFKGSVGPFHTWTPDVYQGAPTPVTAFMAACTKVAAFGAISRVLFVAFDTTRWEWRGVLWAVAIVSMVIGAVLGLTQTDIKRMIAYSSIAHAGFLLLGSMSITEQGVSGTLFYLLAYGFTTLAVFGVISLVRDADGEASHLSQWAGLAKRSPLLAGVMTFLLLALAGIPLTSGFTAKFAVFAAALDDGMAPLVIVALIAS |
Sequence similarities
Belongs to the complex I subunit 2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length539
- Mass (Da)55,428
- Last updated2017-12-20 v1
- Checksum402B4F2EC821D002