A0A292YXH6 · A0A292YXH6_9PSEU
- ProteinCytochrome c oxidase subunit 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids315 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Note: Binds a copper A center.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | respirasome | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Biological Process | electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Pseudonocardia
Accessions
- Primary accessionA0A292YXH6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-82 | Helical | ||||
Sequence: WTWSAIAALIVGVITWGVMFWAV | ||||||
Transmembrane | 103-125 | Helical | ||||
Sequence: LPVEIVFTVIPTIIVAVLFGFTV |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 137-264 | Cytochrome oxidase subunit II copper A binding | ||||
Sequence: APQEKVQVTAFQWNWQFDVDNKRGGTVESLGTSSTIPILVLPTDRSIEFTISSKDVIHSFWVPEFLFKRDVFPMPEKNDTDNVFVIDKIDRTGAFVGRCAELCGSYHSQMNFEVRALPPNLYDAYMSM |
Sequence similarities
Belongs to the cytochrome c oxidase subunit 2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length315
- Mass (Da)34,995
- Last updated2017-12-20 v1
- ChecksumC7BAD7C2DA5D493E