A0A292IIB0 · A0A292IIB0_9MOLU

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site157-159NADP+ (UniProtKB | ChEBI)
Binding site223NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      MAMA39_02940

Organism names

Accessions

  • Primary accession
    A0A292IIB0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-112Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain124-270Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    278
  • Mass (Da)
    30,949
  • Last updated
    2017-12-20 v1
  • Checksum
    354883C0DC6BB32B
MIRLDGKKIAKQIEQELYPITSTKLHHLALIQIGNDFSSSIYIRKKIEACERLKAKTSLIKRIDIKQAELISLINELNYNPSVHGILVQLPLPKNFNVDVVLNAISPMKDVDVFLPATENLVTLSNQSPVPCVVNGILHLKKAYDLDWNKKQIVVVGKGKTGGQPIINWLQKHQYWVQGYEKNDADINIKIQDADVLITAIGNPHVIDSSKLKKGCAFFDVGISRDINNRVIGDINFEIASQTQAAYGTPVPGGIGPMTIVMLLKNLIILKQIQDESK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG937516
EMBL· GenBank· DDBJ
CDN40415.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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