A0A292II93 · A0A292II93_9MOLU

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

Catalytic activity

Features

Showing features for binding site.

145450100150200250300350400450
TypeIDPosition(s)Description
Binding site107-114GTP (UniProtKB | ChEBI)
Binding site189-193GTP (UniProtKB | ChEBI)
Binding site247-250GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle protein
  • EC number
  • Alternative names
    • Fifty-four homolog

Gene names

    • Name
      ffh
    • ORF names
      MAMA39_02970

Organism names

Accessions

  • Primary accession
    A0A292II93

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain268-281SRP54-type proteins GTP-binding

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    50,570
  • Last updated
    2017-12-20 v1
  • Checksum
    65F4DBEE74DCF332
MLKTMIANIVAKKMKKRLDSQTIQKKDIDEVLKEIRIALLDADVNLQVVKKIINEVEQKAVGQMVEVGQDPQQIFLTIIKEELTNILGRKIQGIDYLIKPLKIMLVGLQGSGKTTTVGKLATLLKTKHGKKPMMVALDIYRPAAIDQLKTLSQKVDCGFYEKGIQNPAQTALQALEQAQQNNHDVLLFDTAGRLQTNQELMDELVAIKKAVHPNEILMVVDGLSGQEIINVATEFHHVLKLTGIIITKLDSDARAGAALSLTSILDVPIKFTGIGERLGSLDLFYPERMADRILGLGDVMTLAEKAADTIDEKDTMKTMQKMLSGKMDLDDLMKQMGMMSKIGTLGSIMKMVPGSEKISDNKISEIEEKMRIWKILMSSMTLKERRQPKLLQRELNRKVRIIKGSGRKPDELNKLLKEWDQASKKMADMGKMLQGGKNPFLNFMKGGNGGFGGF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG937516
EMBL· GenBank· DDBJ
CDN40418.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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