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A0A292GNI8 · A0A292GNI8_9MONO

  • Protein
    RNA-directed RNA polymerase L
  • Gene
    L
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.

Catalytic activity

  • GTP + H2O = GDP + phosphate + H+
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H+
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine + H+
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase L
  • EC number
  • Alternative names
    • Large structural protein
    • Replicase
    • Transcriptase

Gene names

    • Name
      L

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 31170197
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Paramyxoviridae > Rubulavirinae > Orthorubulavirus > Orthorubulavirus parotitidis

Accessions

  • Primary accession
    A0A292GNI8

Subcellular Location

Keywords

Interaction

Subunit

Interacts with the P protein.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region644-667Disordered
Domain678-862RdRp catalytic
Domain1797-2010Mononegavirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the paramyxovirus L protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,277
  • Mass (Da)
    258,368
  • Last updated
    2017-12-20 v1
  • MD5 Checksum
    38754996B0B8B4D7742CB852BF35DA86
MGVSQFLSIIKKKQARMAGLNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIRAEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDLRQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAGQDAKDYSIPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVDTRSTLCIIAPELVALYSNEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTASHYLSPLKKRIEILLTLVDDLALLMGDKVYGVVSSLESFVYAQLQYGDPVVDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTAELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILINGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLRIHKCFDASPDEDLSIFMKDKAISCPKQDWMGVFRRSLIKQRYRDANRPLPQPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKATGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTMNQIGIISEHSRRSTADNMTLAHSGSNKHRINNSQFKKNKGSKHEMPDDGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHLFEWIHLRLMRSTLYVGDPFNPPSDSTQLDLDTALNDDIFIVSPRGGIEGLCQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEKKEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRILTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLNAFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNFLSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWSTLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEEEELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEVRPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIARSLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFTWFFLPKGIRLDNDPASNPPIRVPYIGSKTDERRVASMAYIKGASVSLKSALRLAGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRLDDGTTQLKFTPASSYAFSSFVHISNDCQVLEIDDQVTDSNLIYQQVMITGLALIETWNNPPINFSVYETTLHLHTGSSCCIRPVESCVVNPPFLPVPFINIPQMNKFVYDPEPLSLLEXEKIEDIAYQTRIGGLDQIPLLEKIPLLAHLTAKQMVNSITGLDEATSIVNDAVVQADYTSNWISECCYTYIDSVFVYSGWALLLELSYQMYYLRIQGIQGILDYVYMTLRRIPGMAITGISSTISHPRILRRCINLDVIAPINSPHIASLDYTKLSIDAVMWGTKQVLTNISQGIDYEIVVPSESQLTLSDRVLNLVARKLSLLAIIWANYNYPPKVKGMSPEDKCQALTTHLLQTVEYVEHIQIEKTNIRRMIIEPKLTAYPSNLFYLSRKLLNAIRDSEEGQFLIASYYNSFGYLEPILMESKIFNLSSSESASLTEFDFILNLELSEASLEKYSLPSLLMTAENMDNPFPQPPLHHVLRPLGLSSTSWYKTISVLNYISHMKISDGAHLYLAEGSGASMSLIETFLPGEIIWYNSLFNSGENPPQRNFVPLPTQFIESVPYRLIQAGIAAGSGVVQSFYPLWNGNSDITDLSTKTSVEYIIHKVGADTCALVHVDLEGVPGSMNSMLERAQVHALLITVTVLKPGGLLILKASWEPFNRFSFLLTILWQFFSTIRILRSSYSDPNNHEVYIIATLAVDPTTSSFTTALNRARTLNEQGFSLIPPELVSEYWRRRVEQGQIIQDCIDKIISECVRDQYLADNNIILQAGGTPSTRKWLDLPDYPSFNELQSEMARLITIHLKEVIEILKGQSSDHDTLLFTSYNVGPLGKINTILRLIVERILMYTVRNWCVLPTQTRLTLRQSIELGEFRLRDVITPMEILKLSPNRKYLKSALNQSTFNHLMGETSDILLNRSYQKRIWKAIGCVIYCFGLLTPDVEDSERIDIDNDIPDYDIHGDII

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC325486
EMBL· GenBank· DDBJ
BBA66898.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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