A0A291MV67 · A0A291MV67_SPHYA

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site23-28substrate
Binding site55Mg2+ (UniProtKB | ChEBI)
Active site84Proton acceptor
Binding site84Mg2+ (UniProtKB | ChEBI)
Binding site85substrate
Binding site168-171substrate
Binding site191substrate
Binding site196-197substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      A6768_01630

Organism names

Accessions

  • Primary accession
    A0A291MV67

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    22,029
  • Last updated
    2017-12-20 v1
  • Checksum
    D4E4B9D714BDEF86
MSDDYGQEQAIRKLKPGKLVIASHNAGKVREIAALLGPYGIEPISAASLDLPEPEETGTTFIANAELKAMQAADLSGLPALADDSGLCVEALNGDPGLFSARWAGPDKDFGLAMQKVWDGVQAKGPDAGHGAHFICALALAWPDGHVEAFEGRVDGLLVWPPRGANGFGYDAMFQPLGHDISFGEMDPDAKHAMSHRADAFAQLVKAVI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023741
EMBL· GenBank· DDBJ
ATI78820.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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