A0A286ZTE6 · A0A286ZTE6_PIG

  • Protein
    Amyloid-beta A4 protein
  • Gene
    APP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentcell surface
Cellular Componentcell-cell junction
Cellular Componentciliary rootlet
Cellular Componentclathrin-coated pit
Cellular ComponentCOPII-coated ER to Golgi transport vesicle
Cellular Componentdendritic shaft
Cellular Componentdendritic spine
Cellular Componentearly endosome
Cellular Componentextracellular space
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi-associated vesicle
Cellular Componentgrowth cone
Cellular Componentmembrane raft
Cellular Componentneuromuscular junction
Cellular Componentnuclear envelope lumen
Cellular Componentperikaryon
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentpresynaptic active zone
Cellular Componentreceptor complex
Cellular Componentrecycling endosome
Cellular Componentsmooth endoplasmic reticulum
Cellular Componentspindle midzone
Cellular Componentsynaptic vesicle
Molecular Functionheparin binding
Molecular Functionidentical protein binding
Molecular Functionprotein serine/threonine kinase binding
Molecular FunctionPTB domain binding
Molecular Functionreceptor ligand activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionserine-type endopeptidase inhibitor activity
Molecular Functiontransition metal ion binding
Biological Processadult locomotory behavior
Biological Processamyloid fibril formation
Biological Processastrocyte activation involved in immune response
Biological Processaxo-dendritic transport
Biological Processaxon midline choice point recognition
Biological Processcellular response to amyloid-beta
Biological Processcholesterol metabolic process
Biological Processcollateral sprouting in absence of injury
Biological Processcytosolic mRNA polyadenylation
Biological Processdendrite development
Biological Processendocytosis
Biological Processextracellular matrix organization
Biological Processforebrain development
Biological ProcessG2/M transition of mitotic cell cycle
Biological Processgene expression
Biological Processintracellular copper ion homeostasis
Biological Processionotropic glutamate receptor signaling pathway
Biological Processmating behavior
Biological Processmicroglia development
Biological Processmicroglial cell activation
Biological Processmodulation of excitatory postsynaptic potential
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of long-term synaptic potentiation
Biological Processnegative regulation of neuron differentiation
Biological Processnegative regulation of peptidase activity
Biological Processnegative regulation of presynapse assembly
Biological Processneuromuscular process controlling balance
Biological Processneuron apoptotic process
Biological Processneuron cellular homeostasis
Biological Processneuron projection maintenance
Biological Processneuron remodeling
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of amyloid fibril formation
Biological Processpositive regulation of calcium-mediated signaling
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of G2/M transition of mitotic cell cycle
Biological Processpositive regulation of glycolytic process
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of long-term synaptic potentiation
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processpositive regulation of peptidyl-threonine phosphorylation
Biological Processpositive regulation of T cell migration
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor production
Biological Processregulation of long-term neuronal synaptic plasticity
Biological Processregulation of multicellular organism growth
Biological Processregulation of peptidyl-tyrosine phosphorylation
Biological Processregulation of spontaneous synaptic transmission
Biological Processregulation of translation
Biological Processresponse to oxidative stress
Biological Processsmooth endoplasmic reticulum calcium ion homeostasis
Biological Processsuckling behavior
Biological Processsynaptic assembly at neuromuscular junction
Biological Processvisual learning

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amyloid-beta A4 protein

Gene names

    • Name
      APP

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Duroc
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    A0A286ZTE6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane683-705Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-17
ChainPRO_504269400918-752Amyloid-beta A4 protein
Disulfide bond73↔117
Disulfide bond98↔105
Disulfide bond133↔187
Disulfide bond144↔174
Disulfide bond158↔186

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, domain, compositional bias, coiled coil.

Type
IDPosition(s)Description
Region28-123GFLD subdomain
Domain28-189E1
Region131-189CuBD subdomain
Compositional bias196-210Acidic residues
Region196-284Disordered
Compositional bias225-263Acidic residues
Compositional bias267-284Polar residues
Domain291-341BPTI/Kunitz inhibitor
Domain374-565E2
Coiled coil399-459

Sequence similarities

Belongs to the APP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    752
  • Mass (Da)
    85,058
  • Last updated
    2017-11-22 v1
  • Checksum
    8058D98E7C4B3562
MLPGLALVLLAAWTARALEVPTDGNAGLLAEPQVAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRSRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNIDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVADVEEEEAEDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLLKTTQEHLPQDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q2XQ99Q2XQ99_PIGAPP751
Q2XQA0Q2XQA0_PIGAPP695
A0A287B2N2A0A287B2N2_PIGAPP745
A0A288CFW6A0A288CFW6_PIGAPP714

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias196-210Acidic residues
Compositional bias225-263Acidic residues
Compositional bias267-284Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQIR01223372
EMBL· GenBank· DDBJ
HDB78849.1
EMBL· GenBank· DDBJ
Transcribed RNA

Genome annotation databases

Similar Proteins

Disclaimer

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