A0A286ZIV6 · A0A286ZIV6_PIG

  • Protein
    Phosphodiesterase
  • Gene
    PDE1C
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site274Proton donor
Binding site274-278AMP (UniProtKB | ChEBI)
Binding site278Zn2+ 1 (UniProtKB | ChEBI)
Binding site314Zn2+ 1 (UniProtKB | ChEBI)
Binding site315AMP (UniProtKB | ChEBI)
Binding site315Zn2+ 1 (UniProtKB | ChEBI)
Binding site315Zn2+ 2 (UniProtKB | ChEBI)
Binding site422AMP (UniProtKB | ChEBI)
Binding site422Zn2+ 1 (UniProtKB | ChEBI)
Binding site473AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Function3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      PDE1C

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Duroc
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    A0A286ZIV6

Proteomes

Organism-specific databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil80-110
Domain197-574PDEase
Region502-537Disordered
Compositional bias569-618Basic and acidic residues
Region569-704Disordered
Compositional bias633-682Basic and acidic residues
Compositional bias684-704Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    704
  • Mass (Da)
    79,467
  • Last updated
    2022-12-14 v3
  • Checksum
    1C38BCC888ED21BD
MTDASSRKEGFKKCRSATFSIDGYSFTIVANEAGDKTARPLARFSPMESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNNISSSDAKRSTVKSSGSEGSAPINNSVIPVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEDGAAGKAEKKASGEAKTHPVNGTRTNKSDNPHGKNPKAEKSAGEKQQNGDLKEGKNKTDKKDQSNVGNDSKKADGTKKRSHGSPAPSTSSTSCLTLPGDYG

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5G2QCY6A0A5G2QCY6_PIGPDE1C770
A0A287BDV0A0A287BDV0_PIGPDE1C635
A0A5G2R0L7A0A5G2R0L7_PIGPDE1C787
A0A5G2QS39A0A5G2QS39_PIGPDE1C647
F1SIK2F1SIK2_PIGPDE1C687
F1SIK3F1SIK3_PIGPDE1C618
A0A5G2QN37A0A5G2QN37_PIGPDE1C710

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias569-618Basic and acidic residues
Compositional bias633-682Basic and acidic residues
Compositional bias684-704Polar residues

Keywords

Genome annotation databases

Similar Proteins

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