A0A286ZIV6 · A0A286ZIV6_PIG
- ProteinPhosphodiesterase
- GenePDE1C
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids704 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 274 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 274-278 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNLMH | ||||||
Binding site | 278 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 314 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 315 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 315 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 315 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 422 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 422 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 473 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionA0A286ZIV6
Proteomes
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 80-110 | |||||
Sequence: LRKYKKTSQRLRSLVKQLERGEASVVDLKKN | ||||||
Domain | 197-574 | PDEase | ||||
Sequence: VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNNISSSDAKRSTVKSSGSEGSAPINNSVIPVDYKSFKATWTEVVHINRERWRAKVPKE | ||||||
Region | 502-537 | Disordered | ||||
Sequence: ETSQTGGTGQRRSSLNNISSSDAKRSTVKSSGSEGS | ||||||
Compositional bias | 569-618 | Basic and acidic residues | ||||
Sequence: AKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEDGAAGKAEKKASGEA | ||||||
Region | 569-704 | Disordered | ||||
Sequence: AKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEDGAAGKAEKKASGEAKTHPVNGTRTNKSDNPHGKNPKAEKSAGEKQQNGDLKEGKNKTDKKDQSNVGNDSKKADGTKKRSHGSPAPSTSSTSCLTLPGDYG | ||||||
Compositional bias | 633-682 | Basic and acidic residues | ||||
Sequence: NPHGKNPKAEKSAGEKQQNGDLKEGKNKTDKKDQSNVGNDSKKADGTKKR | ||||||
Compositional bias | 684-704 | Polar residues | ||||
Sequence: HGSPAPSTSSTSCLTLPGDYG |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length704
- Mass (Da)79,467
- Last updated2022-12-14 v3
- Checksum1C38BCC888ED21BD
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5G2QCY6 | A0A5G2QCY6_PIG | PDE1C | 770 | ||
A0A287BDV0 | A0A287BDV0_PIG | PDE1C | 635 | ||
A0A5G2R0L7 | A0A5G2R0L7_PIG | PDE1C | 787 | ||
A0A5G2QS39 | A0A5G2QS39_PIG | PDE1C | 647 | ||
F1SIK2 | F1SIK2_PIG | PDE1C | 687 | ||
F1SIK3 | F1SIK3_PIG | PDE1C | 618 | ||
A0A5G2QN37 | A0A5G2QN37_PIG | PDE1C | 710 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 569-618 | Basic and acidic residues | ||||
Sequence: AKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEDGAAGKAEKKASGEA | ||||||
Compositional bias | 633-682 | Basic and acidic residues | ||||
Sequence: NPHGKNPKAEKSAGEKQQNGDLKEGKNKTDKKDQSNVGNDSKKADGTKKR | ||||||
Compositional bias | 684-704 | Polar residues | ||||
Sequence: HGSPAPSTSSTSCLTLPGDYG |
Keywords
- Technical term