A0A286YD35 · A0A286YD35_MOUSE
- ProteinCalcium-activated potassium channel subunit alpha-1
- GeneKcnma1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1209 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- K+(in) = K+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | potassium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCalcium-activated potassium channel subunit alpha-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A286YD35
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 86-108 | Helical | ||||
Sequence: MWWAFLASSMVTFFGGLFIILLW | ||||||
Transmembrane | 179-197 | Helical | ||||
Sequence: VLVVLVFALSIGALVIYFI | ||||||
Transmembrane | 217-235 | Helical | ||||
Sequence: IDMAFNVFFLLYFGLRFIA | ||||||
Transmembrane | 300-321 | Helical | ||||
Sequence: LVNLLSIFISTWLTAAGFIHLV | ||||||
Transmembrane | 336-355 | Helical | ||||
Sequence: ALTYWECVYLLMVTMSTVGY | ||||||
Transmembrane | 367-385 | Helical | ||||
Sequence: LFMVFFILGGLAMFASYVP |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-61 | Disordered | ||||
Sequence: MANGGGGGGGSSGGGGGGGGGSGLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSV | ||||||
Compositional bias | 26-61 | Polar residues | ||||
Sequence: MSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSV | ||||||
Domain | 181-396 | Ion transport | ||||
Sequence: VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKK | ||||||
Domain | 406-523 | Calcium-activated potassium channel slowpoke-like RCK | ||||
Sequence: GRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIIT | ||||||
Domain | 546-633 | Calcium-activated potassium channel BK alpha subunit | ||||
Sequence: DDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAI | ||||||
Region | 703-733 | Disordered | ||||
Sequence: EDEQPPTLSPKKKQRNGGMRNSPNTSPKLMR | ||||||
Compositional bias | 712-730 | Polar residues | ||||
Sequence: PKKKQRNGGMRNSPNTSPK | ||||||
Domain | 784-907 | Calcium-activated potassium channel slowpoke-like RCK | ||||
Sequence: LSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGV | ||||||
Domain | 1029-1149 | Ca2+-activated K+ channel Slowpoke-like C-terminal | ||||
Sequence: ILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLM | ||||||
Compositional bias | 1159-1190 | Polar residues | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRPN | ||||||
Region | 1159-1209 | Disordered | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNRKEMVYR | ||||||
Compositional bias | 1191-1209 | Basic and acidic residues | ||||
Sequence: RPKSRESRDKQNRKEMVYR |
Sequence similarities
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,209
- Mass (Da)134,419
- Last updated2017-11-22 v1
- ChecksumBD1D8315A3BC22D9
Computationally mapped potential isoform sequences
There are 29 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q08460 | KCMA1_MOUSE | Kcnma1 | 1209 | ||
E3VRY6 | E3VRY6_MOUSE | Kcnma1 | 1113 | ||
E3VRY9 | E3VRY9_MOUSE | Kcnma1 | 1192 | ||
E3VRZ4 | E3VRZ4_MOUSE | Kcnma1 | 1113 | ||
F6ZSN2 | F6ZSN2_MOUSE | Kcnma1 | 1108 | ||
E9Q9P4 | E9Q9P4_MOUSE | Kcnma1 | 1053 | ||
A0A286YD59 | A0A286YD59_MOUSE | Kcnma1 | 1171 | ||
A0A286YD36 | A0A286YD36_MOUSE | Kcnma1 | 357 | ||
A0A286YCW3 | A0A286YCW3_MOUSE | Kcnma1 | 1112 | ||
A0A286YCP1 | A0A286YCP1_MOUSE | Kcnma1 | 1185 | ||
A0A286YCQ2 | A0A286YCQ2_MOUSE | Kcnma1 | 1142 | ||
A0A286YCF5 | A0A286YCF5_MOUSE | Kcnma1 | 1119 | ||
A0A286YCI9 | A0A286YCI9_MOUSE | Kcnma1 | 1115 | ||
A0A286YDU9 | A0A286YDU9_MOUSE | Kcnma1 | 1142 | ||
A0A087WQ41 | A0A087WQ41_MOUSE | Kcnma1 | 1178 | ||
A0A286YDM6 | A0A286YDM6_MOUSE | Kcnma1 | 1242 | ||
A0A286YDR7 | A0A286YDR7_MOUSE | Kcnma1 | 1146 | ||
A0A286YE30 | A0A286YE30_MOUSE | Kcnma1 | 1165 | ||
A0A087WQN5 | A0A087WQN5_MOUSE | Kcnma1 | 1239 | ||
A0A286YCZ9 | A0A286YCZ9_MOUSE | Kcnma1 | 1178 | ||
A0A286YDB5 | A0A286YDB5_MOUSE | Kcnma1 | 477 | ||
A0A087WQE1 | A0A087WQE1_MOUSE | Kcnma1 | 634 | ||
A0A286YDC1 | A0A286YDC1_MOUSE | Kcnma1 | 1175 | ||
A0A087WRS4 | A0A087WRS4_MOUSE | Kcnma1 | 1236 | ||
A0A087WSQ4 | A0A087WSQ4_MOUSE | Kcnma1 | 191 | ||
J3QN27 | J3QN27_MOUSE | Kcnma1 | 1132 | ||
J3QMT8 | J3QMT8_MOUSE | Kcnma1 | 1135 | ||
J3QP84 | J3QP84_MOUSE | Kcnma1 | 1059 | ||
A0A1D5RMA3 | A0A1D5RMA3_MOUSE | Kcnma1 | 332 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-61 | Polar residues | ||||
Sequence: MSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSV | ||||||
Compositional bias | 712-730 | Polar residues | ||||
Sequence: PKKKQRNGGMRNSPNTSPK | ||||||
Compositional bias | 1159-1190 | Polar residues | ||||
Sequence: RASLSHSSHSSQSSSKKSSSVHSIPSTANRPN | ||||||
Compositional bias | 1191-1209 | Basic and acidic residues | ||||
Sequence: RPKSRESRDKQNRKEMVYR |
Keywords
- Technical term