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A0A270BBB2 · A0A270BBB2_9SPHN

  • Protein
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • Gene
    dut
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75-77substrate
Binding site88substrate
Binding site92-94substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      CD928_09350

Organism names

  • Taxonomic identifier
  • Strain
    • GW247-27LB
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingopyxis

Accessions

  • Primary accession
    A0A270BBB2

Proteomes

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain26-154dUTPase-like
Region159-181Disordered

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    181
  • Mass (Da)
    18,739
  • Last updated
    2017-12-20 v1
  • MD5 Checksum
    19EEE4957A6D1DECAB83D79FD479FA67
MSSTSVHPLIPIEIRIQRLPNGGGLPLPAYASDGAAGMDVVAAETLTLRPGTRHAVATGFAMAIPPGYEVQVRPRSGLALKHGITCLNTPGTIDSDYRGEVKVILANLSDDNFEIKRGDRIAQLVPAPVQRAAFTEVAALDDTARGAGGFGSTGVASEAAEAEDAAHEGVGSLAAMKMRRP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NIWD01000008
EMBL· GenBank· DDBJ
PAL22312.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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