A0A270BBB2 · A0A270BBB2_9SPHN
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids181 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = dUMP + diphosphate + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 75-77 | substrate | |||
Binding site | 88 | substrate | |||
Binding site | 92-94 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingopyxis
Accessions
- Primary accessionA0A270BBB2
Proteomes
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length181
- Mass (Da)18,739
- Last updated2017-12-20 v1
- MD5 Checksum19EEE4957A6D1DECAB83D79FD479FA67
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NIWD01000008 EMBL· GenBank· DDBJ | PAL22312.1 EMBL· GenBank· DDBJ | Genomic DNA |