A0A265B4Y1 · A0A265B4Y1_SALET

Function

function

Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.

Miscellaneous

4-aminobutanal can spontaneously cyclize to 1-pyrroline, and 5-aminopentanal to 1-piperideine.

Catalytic activity

Pathway

Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.
Amino-acid degradation.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site153-155NAD+ (UniProtKB | ChEBI)
Binding site179-182NAD+ (UniProtKB | ChEBI)
Binding site216NAD+ (UniProtKB | ChEBI)
Binding site232-235NAD+ (UniProtKB | ChEBI)
Active site253
Active site287Nucleophile
Binding site287NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaminobutyraldehyde dehydrogenase (NAD+) activity
Molecular FunctionNAD binding
Biological ProcessL-lysine catabolic process
Biological Processputrescine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Gamma-aminobutyraldehyde dehydrogenase
  • EC number
  • Short names
    ABALDH
  • Alternative names
    • 1-pyrroline dehydrogenase
    • 4-aminobutanal dehydrogenase
    • 5-aminopentanal dehydrogenase
      (EC:1.2.1.-
      ) . EC:1.2.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      patD
    • ORF names
      D6R61_03030
      , DT169_09080
      , FYA03_11125
      , GDM08_00875
      , GDN63_03815

Organism names

Accessions

  • Primary accession
    A0A265B4Y1

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-477Aldehyde dehydrogenase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    51,948
  • Last updated
    2017-12-20 v1
  • Checksum
    6A44022C5049CE71
MTIWENAMQYQLLINGVLVDGEGERQSVYNPATGEVILEIAEASPAQVDAAVLAADSAFAEWGQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLSGLAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAALAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSHYGLASSVWTQDVGRAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVKH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAHMQS010000006
EMBL· GenBank· DDBJ
EBX9256711.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAAKA010000002
EMBL· GenBank· DDBJ
HAA0832340.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAAKJ010000001
EMBL· GenBank· DDBJ
HAA0876753.1
EMBL· GenBank· DDBJ
Genomic DNA
RUBA01000002
EMBL· GenBank· DDBJ
MKI12708.1
EMBL· GenBank· DDBJ
Genomic DNA
CP043214
EMBL· GenBank· DDBJ
QEI79483.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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