A0A263NXS3 · A0A263NXS3_9PSED
- ProteinGDP-L-fucose synthase
- Genefcl
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids311 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Catalytic activity
- GDP-beta-L-fucose + NADP+ = GDP-4-dehydro-alpha-D-rhamnose + H+ + NADPH
Pathway
Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11-17 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GHAGMAG | ||||||
Binding site | 106-109 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: LGSS | ||||||
Site | 108 | Important for catalytic activity | ||||
Sequence: S | ||||||
Site | 110 | Important for catalytic activity | ||||
Sequence: C | ||||||
Active site | 137 | Proton donor/acceptor | ||||
Sequence: Y | ||||||
Binding site | 141 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 164-167 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: PSNL | ||||||
Binding site | 180 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 188 | substrate | ||||
Sequence: K | ||||||
Binding site | 203 | substrate | ||||
Sequence: W | ||||||
Binding site | 210 | substrate | ||||
Sequence: R | ||||||
Binding site | 270 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GDP-L-fucose synthase activity | |
Molecular Function | isomerase activity | |
Molecular Function | NADP+ binding | |
Biological Process | 'de novo' GDP-L-fucose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGDP-L-fucose synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A263NXS3
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-238 | NAD-dependent epimerase/dehydratase | ||||
Sequence: VYVAGHAGMAGSAIQRRLSAAGFSNFVTRSHAELDLTQQAAVDAFFAAEKPEIVFLAAGRVGGIKANNNFRAEFIYQNLMIEANVIHSAWKHGVQRLLFLGSSCIYPRDCPQPIHEDYLLTGPLEQTNEPYAVAKILGVKLCENYHRQYGAQFIAVMPSNLYGPNDSYDLENCHVLPALISKAHAAKMSGASELVVWGSGLPRREFLYVEDMADACVHLMESDIKSGLFNVG |
Sequence similarities
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)34,291
- Last updated2017-12-20 v1
- Checksum8AE4FAA473607C00