A0A263NXJ3 · A0A263NXJ3_9PSED

  • Protein
    Dihydroorotate dehydrogenase (quinone)
  • Gene
    pyrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site61-65FMN (UniProtKB | ChEBI)
Binding site65substrate
Binding site85FMN (UniProtKB | ChEBI)
Binding site110-114substrate
Binding site138FMN (UniProtKB | ChEBI)
Binding site171FMN (UniProtKB | ChEBI)
Binding site171substrate
Active site174Nucleophile
Binding site176substrate
Binding site216FMN (UniProtKB | ChEBI)
Binding site244FMN (UniProtKB | ChEBI)
Binding site245-246substrate
Binding site267FMN (UniProtKB | ChEBI)
Binding site296FMN (UniProtKB | ChEBI)
Binding site317-318FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      B7453_05365

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IB20
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A263NXJ3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain46-333Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    35,776
  • Last updated
    2017-12-20 v1
  • Checksum
    DA38D056A9FFC4B7
MYTLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLVCKAPAKMPVSVMGLDFPNPVGLAAGLDKNGAAIDGFAQLGFGFVEIGTVTPRPQPGNPKPRIFRLPEAEAIINRMGFNNLGVDHLLSRVHAAKYKGILGINIGKNFDTPVERAVDDYLICLDKVYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLEALRQRQEDLAVRHGKRVPLAIKIAPDMSDEETVLVAQALVDSGMDAVIATNTTLSRVGVEGLAHGDEAGGLSGAPVRDKSTHTVKVLAAELAGRLPIIAVGGITEGKHAAEKIAAGASLVQLYTGFIYKGPALIRESVDAIAALR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NMRE01000008
EMBL· GenBank· DDBJ
OZO05517.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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