A0A263NW34 · A0A263NW34_9PSED
- ProteinType III pantothenate kinase
- GenecoaX
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids249 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Catalytic activity
- (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H+
Cofactor
Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )
Note: A monovalent cation. Ammonium or potassium.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 6-13 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DCGNSFIK | ||||||
Binding site | 93 | substrate | ||||
Sequence: Y | ||||||
Binding site | 100-103 | substrate | ||||
Sequence: GLDR | ||||||
Active site | 102 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 122 | K+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 125 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 181 | substrate | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | pantothenate kinase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameType III pantothenate kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A263NW34
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length249
- Mass (Da)26,768
- Last updated2017-12-20 v1
- Checksum41B1B67A684A998A