A0A263HAU7 · A0A263HAU7_9PAST

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14substrate
Binding site41Mg2+ (UniProtKB | ChEBI)
Active site70Proton acceptor
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site157-160substrate
Binding site180substrate
Binding site185-186substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      NCTC10851_01644

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC10851
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Actinobacillus

Accessions

  • Primary accession
    A0A263HAU7

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,102
  • Last updated
    2017-12-20 v1
  • Checksum
    270E3A202576ED76
MKQKIVLATGNQGKVKEMADVLAEFGFDVVAQTDLGIESPEETGLTFVENALIKARHAATISGLPAIADDTGLVVPALGGAPGLYSARYAGVDGHEAEAKNRQKLLAELADLPPQQRQAKFVSCIVLLQHPTDPSPIIAEGECFGQIGFTEKGENGFGYDSLFISDDAHCTFAELATAEKKKISHRAKALSVLKVRLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UFSB01000001
EMBL· GenBank· DDBJ
SUU37622.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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