A0A261Q3S6 · A0A261Q3S6_9BACT
- ProteinNADH-quinone oxidoreductase subunit N
- GenenuoN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids466 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Catalytic activity
- a quinone + 5 H+(in) + NADH = a quinol + 4 H+(out) + NAD+
CHEBI:132124 + 5 H+ (in)CHEBI:15378+ CHEBI:57945 = CHEBI:24646 + 4 H+ (out)CHEBI:15378+ CHEBI:57540
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH:ubiquinone reductase (non-electrogenic) activity | |
Molecular Function | quinone binding | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit N
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Cytophagia > Cytophagales > Cytophagaceae > Siphonobacter
Accessions
- Primary accessionA0A261Q3S6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-43 | Helical | ||||
Sequence: VLLPATLLFLLVALVLNSL | ||||||
Transmembrane | 63-83 | Helical | ||||
Sequence: VNFSAIVLVTSLFVVGLSRTF | ||||||
Transmembrane | 95-112 | Helical | ||||
Sequence: YYAILLFSIAGALMMIGF | ||||||
Transmembrane | 118-135 | Helical | ||||
Sequence: LFVGVEVLSVAMYVLTGT | ||||||
Transmembrane | 147-169 | Helical | ||||
Sequence: LKYFLMGSFATGILLFGVAMIYG | ||||||
Transmembrane | 189-209 | Helical | ||||
Sequence: YGSVSPLLYVGLLLLFIGMLF | ||||||
Transmembrane | 230-255 | Helical | ||||
Sequence: IFTAFMSTVVKTAGFAALYKLASVAF | ||||||
Transmembrane | 261-283 | Helical | ||||
Sequence: FWAQTMAIVTVLTLLVGNITAAY | ||||||
Transmembrane | 290-311 | Helical | ||||
Sequence: MMGYSSISHAGYLLLGVVANVS | ||||||
Transmembrane | 317-338 | Helical | ||||
Sequence: ILFYSLAYSLATVSAFGVLMVV | ||||||
Transmembrane | 364-386 | Helical | ||||
Sequence: LLAFVMTISMLSLAGIPLTAGFW | ||||||
Transmembrane | 398-419 | Helical | ||||
Sequence: ANLTSLLVIAVLMSCVGIYYYF | ||||||
Transmembrane | 440-458 | Helical | ||||
Sequence: GFKLTLLLTTALTLLLGVF |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 114-412 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: NLIMLFVGVEVLSVAMYVLTGTDKRNLRSNEAALKYFLMGSFATGILLFGVAMIYGATGSFKLGGIATYVEVAIRYGSVSPLLYVGLLLLFIGMLFKVSAAPFHFWTPDVYEGAPTIFTAFMSTVVKTAGFAALYKLASVAFGGAYGFWAQTMAIVTVLTLLVGNITAAYQTSFKRMMGYSSISHAGYLLLGVVANVSASPSAILFYSLAYSLATVSAFGVLMVVSEKKLYEGGADERYEAFNGLAKSNPLLAFVMTISMLSLAGIPLTAGFWGKFFIFSAAVEANLTSLLVIAVLMSC |
Sequence similarities
Belongs to the complex I subunit 2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length466
- Mass (Da)50,493
- Last updated2017-12-20 v1
- ChecksumF868C616D680AC6C
Keywords
- Technical term