A0A260VUV2 · A0A260VUV2_9NOCA

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site109Transition state stabilizer
Active site113Proton acceptor
Binding site277Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • ORF names
      CH295_01865

Organism names

  • Taxonomic identifier
  • Strain
    • 14-2483-1-2
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Rhodococcus

Accessions

  • Primary accession
    A0A260VUV2

Proteomes

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link236↔262Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-112)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues
Region1-29Disordered
Domain146-443Plant heme peroxidase family profile
Region358-384Disordered

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    737
  • Mass (Da)
    81,051
  • Last updated
    2021-09-29 v1
  • Checksum
    3188BD90BE7B484B
MSEDHVTREKEMNEDQPQESGGKCPVMHDSMPMPVEGGGNREWWPKALNLKILKKNPAVGDPMGADYDYAAEFNSLDLAEVKRDIEALMTNSQPWWPADFGHYGPFFIRMAWHAAGTYRKQDGRGGAGAGMQRFAPLNSWPDNASLDKARRLIWPVKQKYGRKLSWADLIVLTGNVAIESMGLPTYGFAGGRVDAWEPDEDVYWGPEQTWLGDERYNGDRTSLENPLAAVQMGLIYVNPEGPNGNPDPVQSALDIRETFGRMAMNDIETAALAVGGHTFGKTHGAADPDEHIGAEPEGAPIEQMGLGWKNSYQSGVGADAITSGLEVIWTPTPTQWDNSFLETLYGFEWELHKSPAGAHQWRPKNGEGADLVPDPADPTKRRHPSMLTSDIAMRVDPIYEQITRRWLDHPEELAEEFQKAWFKLTHRDMGPVSRYLGPEVPSETLLWQDPIPAVDHELIGEAQIAELKQAILGSELTQDQLISAAWAAASSFRVSDKRGGANGGRLRLQPQAGWEVNEPDEIAQVIRVLEGIQQSFSGTVSFADLVVLGGVAALEQASGVSVPFTPGRMDATQEQTDVDSFSDLEPKADGFRNFLGKGQKLPAEYSLIDRANLLSLSAPEMTVLVGGLRVLGANFGKSSHGVLTDKVGTLTNDFFVNLLDMGTEWVPTAEDGIYEAKDAATGEKKWTGTRNDLVFGSNSELRALAEVYACDDAKDKFVADFVAAWDKVMMLDRFELS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-17Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NPFW01000002
EMBL· GenBank· DDBJ
OZF40348.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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