A0A258UJY1 · A0A258UJY1_9GAMM

Function

function

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site249Zn2+ (UniProtKB | ChEBI)
Binding site312Zn2+ (UniProtKB | ChEBI)
Binding site313Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethionine synthase activity
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine synthase
  • EC number
  • Alternative names
    • 5-methyltetrahydrofolate--homocysteine methyltransferase

Gene names

    • ORF names
      B7Y29_07375

Organism names

Accessions

  • Primary accession
    A0A258UJY1

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-327Hcy-binding
Domain358-576Pterin-binding

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    576
  • Mass (Da)
    62,311
  • Last updated
    2017-12-20 v1
  • Checksum
    D905252E4261E013
MNTTTARRHSFRQALNERTLILDGAMGTMIQGYKLQEDDFRGQRFVDHPIDLKGNNDLLTLTRPDVIGAIHRAYLDAGAQILETNTFNSTSVAQEDYDMAHLVTELNREGAALARKVADEFSVETGKAAWVAGVLGPTSKTLSLSPDVNDPGYRATTFAAVKAAYREAAMALLEGGADILMIETIFDTLNAKAAIYAILELIDERGEDIPIWISGTITDASGRTLSGQTLEAFYHSVRHAKPVAIGLNCALGPAELRPYVEELSRIAECRVSVHPNAGLPNEFGEYDLAAAEMAKEVGEWAANGWLNIAGGCCGSTPAHIAAIAAAVTAHPPRVIPEIPVYTRLSGLEPLILDERIVFANVGERTNVTGSALFRRLIKEGNYTEALSIALKQVENGAQIIDINMDEGMLDAVKEMTTFVNLIAAEPDIARVPVMVDSSKWEAIVAGLSCLQGKGIVNSISLKEGEAKFLEQAKVLRYFGAATVVMAFDEVGQADTYARKVEICTRAYNLLVANGFPPEDIIFDPNVFAIATGIEEHNNYAVDFIEATRTIKQTLPHCHISGGVSNVSFSFRGNNPV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue576

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NCGV01000121
EMBL· GenBank· DDBJ
OYZ04000.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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