A0A257E7C9 · A0A257E7C9_9BURK

Function

function

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site56-57NAD+ (UniProtKB | ChEBI)
Binding site134NAD+ (UniProtKB | ChEBI)
Binding site180-182NAD+ (UniProtKB | ChEBI)
Binding site200NAD+ (UniProtKB | ChEBI)
Binding site246-247NAD+ (UniProtKB | ChEBI)
Binding site271-275NAD+ (UniProtKB | ChEBI)
Binding site281-282NAD+ (UniProtKB | ChEBI)
Binding site332NAD+ (UniProtKB | ChEBI)
Active site420
Binding site502NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionurocanate hydratase activity
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocanate hydratase
  • EC number
  • Short names
    Urocanase
  • Alternative names
    • Imidazolonepropionate hydrolase

Gene names

    • Name
      hutU
    • ORF names
      CFE38_21100

Organism names

Accessions

  • Primary accession
    A0A257E7C9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-141Urocanase N-terminal
Domain144-358Urocanase Rossmann-like
Domain361-555Urocanase C-terminal

Sequence similarities

Belongs to the urocanase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    565
  • Mass (Da)
    61,400
  • Last updated
    2017-12-20 v1
  • Checksum
    E08C35ED9C24F8EC
MTPSIDPRLDPTRVVRAPRGSTLTCKNWVTEAAYRMIQNNLDAEVAENPQSLVVYGGIGRAARDWACFDQILASLKDLNEDESLLIQSGKPVGVFKTHANAPRVLIANSNLVPKWANWEHFNELDRKGLFMYGQMTAGSWIYIGTQGIVQGTFETFVEAGRQHYNNDWTGRWILTAGLGGMGGAQPLAATLAGACSLNIECQQSSIDFRLRTRYVDKQAKDLDDALALIAHHTAAKEAVSIALLGNAAEVLPELVRRAQAGGMRPDLVTDQTSAHDLINGYLPPGWTVAQWKAAQHDPAQHARLKADASQGCATQVQAMLDFQAMGIPTVDYGNNIRQVAFDHGVSNAFDFPGFVPAYIRPMFCEGKGPFRWVALSGDPEDIYKTDAKIKELFPNNTHTHRWLDMARERISFQGLPARICWLGLGERHLAGLAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGTDAVSDWPLLNALLNTAGGASWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAERLARVLVNDSASGVMRHADAGYELAVATAKKQGLKLPMIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NKIP01000054
EMBL· GenBank· DDBJ
OYU09726.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp