A0A257E7C9 · A0A257E7C9_9BURK
- ProteinUrocanate hydratase
- GenehutU
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids565 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity
- 4-imidazolone-5-propanoate = trans-urocanate + H2O
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 56-57 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 134 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 180-182 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GMG | ||||||
Binding site | 200 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 246-247 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NA | ||||||
Binding site | 271-275 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QTSAH | ||||||
Binding site | 281-282 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: YL | ||||||
Binding site | 332 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Active site | 420 | |||||
Sequence: C | ||||||
Binding site | 502 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | urocanate hydratase activity | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrocanate hydratase
- EC number
- Short namesUrocanase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae
Accessions
- Primary accessionA0A257E7C9
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-141 | Urocanase N-terminal | ||||
Sequence: VRAPRGSTLTCKNWVTEAAYRMIQNNLDAEVAENPQSLVVYGGIGRAARDWACFDQILASLKDLNEDESLLIQSGKPVGVFKTHANAPRVLIANSNLVPKWANWEHFNELDRKGLFMYGQMTAGSWI | ||||||
Domain | 144-358 | Urocanase Rossmann-like | ||||
Sequence: GTQGIVQGTFETFVEAGRQHYNNDWTGRWILTAGLGGMGGAQPLAATLAGACSLNIECQQSSIDFRLRTRYVDKQAKDLDDALALIAHHTAAKEAVSIALLGNAAEVLPELVRRAQAGGMRPDLVTDQTSAHDLINGYLPPGWTVAQWKAAQHDPAQHARLKADASQGCATQVQAMLDFQAMGIPTVDYGNNIRQVAFDHGVSNAFDFPGFVPAY | ||||||
Domain | 361-555 | Urocanase C-terminal | ||||
Sequence: PMFCEGKGPFRWVALSGDPEDIYKTDAKIKELFPNNTHTHRWLDMARERISFQGLPARICWLGLGERHLAGLAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGTDAVSDWPLLNALLNTAGGASWVSLHHGGGVGMGYSQHSGMVIVADGTDAAAERLARVLVNDSASGVMRHADAGYELAVATAK |
Sequence similarities
Belongs to the urocanase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length565
- Mass (Da)61,400
- Last updated2017-12-20 v1
- ChecksumE08C35ED9C24F8EC