A0A256XHQ9 · A0A256XHQ9_9CREN

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

145450100150200250300350400450
TypeIDPosition(s)Description
Binding site106-113GTP (UniProtKB | ChEBI)
Binding site189-193GTP (UniProtKB | ChEBI)
Binding site247-250GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle 54 kDa protein
  • EC number
  • Short names
    SRP54

Gene names

    • Name
      srp54
    • ORF names
      B6V02_00325

Organism names

Accessions

  • Primary accession
    A0A256XHQ9

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain1-85Signal recognition particle SRP54 helical bundle
Domain98-250AAA+ ATPase
Domain99-295SRP54-type proteins GTP-binding
Coiled coil302-329

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    52,055
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    6484E5C720A12E05FAFFB21DDC36BD80
MKILVESFTKLISRIKGLKYIDEETLRELLKELQKILLKADVSVQTIYTITKTIEEKFKNTKPPEGISIKDYLIYLLYQELINALGGDYELKIELPKRPYKLMLIGVEGCGKTTSAAKIAKLYLRKKFRVGLIETDTHRPGAQDQLKQLADRVGALFYGDLKVKMSSDEILVKGLEYMLKSRADLIIIDTAGRHKSEEDLMSEVKRLYELAQPDEVMLVIDATSGKQAATQAEAFMKYVPIHSIFITKMDSTARGGGALMSVIKTGAKIKFIGIGEDVDEIELFNPRRFVSRLLGMGDLETLVEKIRSIEEEEKLVKEIEKDIEEGKFTLLTVKKQIESILKLGPLSKLLQLLPTSMFPNVILKNIDEEQAQLTQERMRRWYVILNSMTREELLNPDILNASRIRRIAKGSGTSPRDIKELLQYYQLMRRWISSLKKSRRRLLKFFEKGFPQSI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NJDF01000004
EMBL· GenBank· DDBJ
OYT27190.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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