A0A256BG02 · A0A256BG02_9CYAN

Function

function

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site174Mg2+ 2 (UniProtKB | ChEBI)
Binding site174Mg2+ 1 (UniProtKB | ChEBI)
Binding site213Mg2+ 1 (UniProtKB | ChEBI)
Binding site238Mg2+ 1 (UniProtKB | ChEBI)
Binding site301Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroneopterin aldolase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological Processfolic acid biosynthetic process
Biological ProcessRNA catabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      rnhA
    • ORF names
      B9G53_09850

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SR411
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Pseudanabaenales > Pseudanabaenaceae > Pseudanabaena

Accessions

  • Primary accession
    A0A256BG02

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias122-151Polar residues
Region122-164Disordered
Domain165-309RNase H type-1

Sequence similarities

Belongs to the DHNA family.
Belongs to the RNase H family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    312
  • Mass (Da)
    34,854
  • Last updated
    2017-12-20 v1
  • Checksum
    7535468ECED9BB50
MTTSKNFNKIYLKGVRAYGYVGYLPEENVLGQWFEVDATLWVDFEKSTHNDEIEDTVNYISCIRKIETLIQTQKFKLIERLVGAIADSLLEDPKIAQVEVKVIKHPPIPNFQGSVAVEIVRSRSHSPTTSAAKTTQAKLETSIQTESSPEPKTESPKSKAEDAGTPKIISIHTDGACSKNPGPGGWGVVIHFSDGSTKELGGGIRETTNNQMELQGAIAALEFLATHKQSTPVDLYTDSKYVLDGITKWIKGWKKNGWKTKDNKPVKNQEFWQQLDPLNTSNIRWHWVEGHSGDPDNERCDAIARSYTAQHM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias122-151Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NDHW01000101
EMBL· GenBank· DDBJ
OYQ64788.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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