A0A256BG02 · A0A256BG02_9CYAN
- ProteinRibonuclease H
- GenernhA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity
- 7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
Cofactor
Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroneopterin aldolase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleic acid binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | folic acid biosynthetic process | |
Biological Process | RNA catabolic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease H
- EC number
- Short namesRNase H
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Pseudanabaenales > Pseudanabaenaceae > Pseudanabaena
Accessions
- Primary accessionA0A256BG02
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 122-151 | Polar residues | ||||
Sequence: SRSHSPTTSAAKTTQAKLETSIQTESSPEP | ||||||
Region | 122-164 | Disordered | ||||
Sequence: SRSHSPTTSAAKTTQAKLETSIQTESSPEPKTESPKSKAEDAG | ||||||
Domain | 165-309 | RNase H type-1 | ||||
Sequence: TPKIISIHTDGACSKNPGPGGWGVVIHFSDGSTKELGGGIRETTNNQMELQGAIAALEFLATHKQSTPVDLYTDSKYVLDGITKWIKGWKKNGWKTKDNKPVKNQEFWQQLDPLNTSNIRWHWVEGHSGDPDNERCDAIARSYTA |
Sequence similarities
Belongs to the DHNA family.
Belongs to the RNase H family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)34,854
- Last updated2017-12-20 v1
- Checksum7535468ECED9BB50
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 122-151 | Polar residues | ||||
Sequence: SRSHSPTTSAAKTTQAKLETSIQTESSPEP |
Keywords
- Technical term