A0A252E531 · A0A252E531_9NOSO

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14substrate
Binding site39Mg2+ (UniProtKB | ChEBI)
Active site68Proton acceptor
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site147-150substrate
Binding site170substrate
Binding site175-176substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      BV372_12920

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • T09
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Nostoc

Accessions

  • Primary accession
    A0A252E531

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    20,854
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    45170B3F1587696F4DBD558191DD007E
MTKLLVVATGNPGKLREMQAYLANSGWELTLKPEELEIEETGDTFAANACLKASQIAQATGNWAIADDSGLQVDGLNGAPGVYSARYGKTDSERIARVLNELGSDVNRQAQFVCVVAIASPDGAIVLQSEGICRGTILHAPRGHGGFGYDPIFYIPEKQLTFAEMTPQMKRSISHRGKAFTALLPQLAVLSPEY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MTAV01000053
EMBL· GenBank· DDBJ
OUL34749.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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