A0A252DR60 · A0A252DR60_9NOSO

  • Protein
    Uracil phosphoribosyltransferase
  • Gene
    upp
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site845-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1095-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site137-1455-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site202uracil (UniProtKB | ChEBI)
Binding site207-209uracil (UniProtKB | ChEBI)
Binding site2085-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      BV375_15000

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 106C
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Nostoc

Accessions

  • Primary accession
    A0A252DR60

Proteomes

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    23,424
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    9E8317297887DA0A541DAE7F59F7E6C1
MTLQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAMVELGRWLTYEAAREWLPTQETTVQSPLDSSPATLINPEVPVAVVPILRAGLGLLEGAQTLLPLASIYHLGLVRNEETLQPFCYLNKLPEKFDPQTRVLITDPMLATGGSMMAAMAELTQRGVDPVLTRIVCVVAAPPALQKLSAAYPGLIIYTATIDEIVNDQGYIVPGLGDAGDRTFGT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MTAW01000107
EMBL· GenBank· DDBJ
OUL29919.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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