A0A248X3C7 · A0A248X3C7_9HYME

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Proctotrupomorpha > Chalcidoidea > Agaonidae > Agaoninae > Ceratosolen

Accessions

  • Primary accession
    A0A248X3C7

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane49-72Helical
Transmembrane84-109Helical
Transmembrane129-152Helical
Transmembrane164-192Helical
Transmembrane212-235Helical
Transmembrane247-272Helical
Transmembrane284-305Helical
Transmembrane317-340Helical
Transmembrane360-386Helical
Transmembrane398-417Helical
Transmembrane437-458Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_501249032926-507Cytochrome c oxidase subunit 1

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-493Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    507
  • Mass (Da)
    57,183
  • Last updated
    2017-11-22 v1
  • Checksum
    8A453BE911F0FAEB
LYMIFGSWAGLFGVLLSMMMRLELASPGNFFGNDQLYNTVVTGHAMTMIFFFIMPTMFGGFGNYLVPLMLGAPDMAFPRMNNMSFWLLPPAFLFLLMSVINDVGAGTGWTMYPPLSSKPFHSGVSVDYMIFSLHLGGISSIMGSINMIATIFNMKIVPLMKLPLFIWSMLITSFLILLAMPVLAGALTMLLFDRNFNTSFFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLISHIVLMESYKKVMFGHIGMVFAMLSIGILGFVVWGHHMFTVGMDVDTRAYFTSATMVIGVPTGIKVYSWVCTLYGSKFKVSVPLLWVFGFIFLFTVGGVSGVMLANAALDVVLHDTYYVVAHFHYVLSMGAVFAIMGSFIFWFPLMSGIYLNQKLLKMQFWSLFLGVNLTFFPQHFLGLSGMPRRYSDYPDAYMCWNKLSSLGAMLSFLSTMFFFGIVLEGLMSNRKLIFSGKMNISLEWMMTYPPMEHSFDELPKVFFMENNKFNSLNLLK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue507

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX668810
EMBL· GenBank· DDBJ
ASW22939.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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