A0A246BCC5 · A0A246BCC5_9FLAO

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site49-53GTP (UniProtKB | ChEBI)
Binding site54Zn2+ (UniProtKB | ChEBI); catalytic
Binding site65Zn2+ (UniProtKB | ChEBI); catalytic
Binding site67Zn2+ (UniProtKB | ChEBI); catalytic
Binding site70GTP (UniProtKB | ChEBI)
Binding site91-93GTP (UniProtKB | ChEBI)
Binding site113GTP (UniProtKB | ChEBI)
Active site125Proton acceptor
Active site127Nucleophile
Binding site148GTP (UniProtKB | ChEBI)
Binding site153GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA
    • ORF names
      AP75_02335

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 19056
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Weeksellaceae > Chryseobacterium group > Kaistella

Accessions

  • Primary accession
    A0A246BCC5

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-168GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    23,218
  • Last updated
    2017-10-25 v1
  • MD5 Checksum
    E4F7519F25778140897F54812F4EE21A
MLKIQAEANVPTEYGNFRMIAFSEQESDWMPHMAIIAENTDFSKPVNVRFHSECITGEVFHSKKCECGQQLDAAMKFMHENGGIIIYLRQEGRNIGIINKLKAYALQEQGFDTVEANLKLGLPADDRDFSAAIEILNLLEVKEINLLTNNPEKMKIVENSNVILNKRIPLQITATKESESYLKVKKDYFGHLLIDKTDPDKKTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JASZ02000002
EMBL· GenBank· DDBJ
OWK99337.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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