A0A246BCC5 · A0A246BCC5_9FLAO
- ProteinGTP cyclohydrolase-2
- GeneribA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids204 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Catalytic activity
- GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 49-53 | GTP (UniProtKB | ChEBI) | |||
Binding site | 54 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 65 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 67 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 70 | GTP (UniProtKB | ChEBI) | |||
Binding site | 91-93 | GTP (UniProtKB | ChEBI) | |||
Binding site | 113 | GTP (UniProtKB | ChEBI) | |||
Active site | 125 | Proton acceptor | |||
Active site | 127 | Nucleophile | |||
Binding site | 148 | GTP (UniProtKB | ChEBI) | |||
Binding site | 153 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3,4-dihydroxy-2-butanone-4-phosphate synthase activity | |
Molecular Function | GTP binding | |
Molecular Function | GTP cyclohydrolase II activity | |
Molecular Function | zinc ion binding | |
Biological Process | riboflavin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase-2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Weeksellaceae > Chryseobacterium group > Kaistella
Accessions
- Primary accessionA0A246BCC5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length204
- Mass (Da)23,218
- Last updated2017-10-25 v1
- MD5 ChecksumE4F7519F25778140897F54812F4EE21A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JASZ02000002 EMBL· GenBank· DDBJ | OWK99337.1 EMBL· GenBank· DDBJ | Genomic DNA |