A0A243RWL2 · A0A243RWL2_9ACTN
- ProteinTranscriptional regulator WhiB
- GenewhiB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 34 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 37 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 43 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | dinitrosyl-iron complex binding | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein-disulfide reductase (NAD(P)H) activity | |
Biological Process | cell redox homeostasis | |
Biological Process | negative regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscriptional regulator WhiB
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Streptosporangium
Accessions
- Primary accessionA0A243RWL2
Proteomes
Subcellular Location
PTM/Processing
Post-translational modification
The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length98
- Mass (Da)11,196
- Last updated2017-10-25 v1
- ChecksumAFA3172FB1648086
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NGFP01000006 EMBL· GenBank· DDBJ | OUC99572.1 EMBL· GenBank· DDBJ | Genomic DNA |