A0A243RWL2 · A0A243RWL2_9ACTN

Function

function

Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.

Features

Showing features for binding site.

198102030405060708090MWITDWTSRAACKGADPDALFVQGAAQNRAKLICRGCPVRTECLADALDNRIEFGVWGGMTERERRALLRRRPDVDSWRDLLELAKEEYERTNELIAG
TypeIDPosition(s)Description
Binding site12[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site34[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site37[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site43[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functiondinitrosyl-iron complex binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionprotein-disulfide reductase (NAD(P)H) activity
Biological Processcell redox homeostasis
Biological Processnegative regulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulator WhiB

Gene names

    • Name
      whiB
    • ORF names
      CA984_02425

Organism names

  • Taxonomic identifier
  • Strain
    • M26
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Streptosporangium

Accessions

  • Primary accession
    A0A243RWL2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Post-translational modification

The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-674Fe-4S Wbl-type

Sequence similarities

Belongs to the WhiB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    98
  • Mass (Da)
    11,196
  • Last updated
    2017-10-25 v1
  • Checksum
    AFA3172FB1648086
MWITDWTSRAACKGADPDALFVQGAAQNRAKLICRGCPVRTECLADALDNRIEFGVWGGMTERERRALLRRRPDVDSWRDLLELAKEEYERTNELIAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NGFP01000006
EMBL· GenBank· DDBJ
OUC99572.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help