A0A243RRL4 · A0A243RRL4_9ACTN

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site75substrate
Binding site214-216substrate
Binding site223Mn2+ (UniProtKB | ChEBI)
Binding site243Mn2+ (UniProtKB | ChEBI)
Binding site265substrate
Binding site266-271GTP (UniProtKB | ChEBI)
Active site267
Binding site290Mn2+ (UniProtKB | ChEBI)
Binding site380-382substrate
Binding site382GTP (UniProtKB | ChEBI)
Binding site413GTP (UniProtKB | ChEBI)
Binding site507-510GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      CA984_10710

Organism names

  • Taxonomic identifier
  • Strain
    • M26
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Streptosporangium

Accessions

  • Primary accession
    A0A243RRL4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-235Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain239-593Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    604
  • Mass (Da)
    67,120
  • Last updated
    2017-10-25 v1
  • MD5 Checksum
    A18EBF50D05E9DB9BA3A3A64585F3DD7
MADVTAPSPTSHPELAAWVKEIAELTQPDRIEWCDGSEAEWTRLTNLLVKQGTFKRLAKRQNSFYAASDPSDVARVEDRTYICSEREEDAGPTNNWIAPAEMRRTFGEIFRGSMRGRTMYVVPFCMGPLGGDISQLGVEITDSPYVVVSMRVMTRMGERALRLIEERGGYVKAVHSVGSPLEQGQADVPWPCNPTKYISHFPETREIWSYGSGYGGNALLGKKCYALRIASTMARDEGWLAEHMLILKLTPPSGETRYVAAAFPSACGKTNLAMLQPTIPGWKVETVGDDIAWMRFGADGRLYAINPEAGFFGVAPGTGESTNANAIKTLWGNSIFTNVALTDDGDVWWEGLTDQPPAHLTDWKGRSWTPDSQEPAAHPNARFAVPAAQCPTIAPEWQDPRGVPISAILFGGRRATAVPLVTESLSWQHGVFTGANIASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYFAHWIKVGQREDVRLPRIYYVNWFRKNDDGAFIWPGFGENSRVLKWVVDRLNGEAEAVRTPIGLLPAELDTDGLDISDEDLRTLLSVDREVWKEEASLIPAFFETFGDHFPKELWEEYEALVDRLNQDSGTRPN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NGFP01000036
EMBL· GenBank· DDBJ
OUC97529.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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