A0A242BHS1 · A0A242BHS1_ENTFC

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13substrate
Binding site36substrate
Binding site63-72substrate
Active site65Proton donor
Binding site126substrate
Binding site188substrate
Binding site197substrate
Binding site217substrate
Binding site218substrate
Binding site3375-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3415-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site3435-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site363-3715-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site367orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )
  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • Synonyms
      pyrF
    • ORF names
      A5810_001237

Organism names

Accessions

  • Primary accession
    A0A242BHS1

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-233Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.
In the C-terminal section; belongs to the OMP decarboxylase family.
In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    450
  • Mass (Da)
    49,806
  • Last updated
    2017-10-25 v1
  • Checksum
    F9A23D0FAA75006A
MNQLNQRPIIALDFSTWQEVEDFLRFFPEEEKLFVKIGMELFYQEGPEIVRYLKDAGHDVFLDLKLHDIPNTVEKAMRGLAKLGVDVTCVHAAGGIRMMEAAMRGLEEGTPEGGKRPLLLAITQLTSTSEEEMHADQLIEVPLEKSVIHYANCAKKAGLDGVVSSAWEVEAIKETAGDEFVCLTPGIRPEGTVAGDQTRVVTPSQAREIGSTFIVVGRPITQATDPYEAYRTIQTEWSQPKMNVEQSIAKDLLEIEAVFLNPSDPFTWASGIKSPIYCDNRITMSYPNVRKEIAKGLASKIKEAFPEVQVIAGTATAGIPHAAWVAEILDLPMVYIRSKAKDHGKGNQIEGRIVEGQKMVVIEDLISTGGSVLEAAEAAKREGADILGVAAIFTYELPKGKANFEKAEIPLMTLTNYSVLIEAALEDRYIDEQELTLLKEWKKDPENWQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NGKW01000002
EMBL· GenBank· DDBJ
OTN94991.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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