A0A237QZ82 · A0A237QZ82_KLEPN
- ProteinMercuric reductase
- GenemerA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids560 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
Catalytic activity
- Hg + NADP+ + H+ = Hg2+ + NADPH
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 144 | FAD (UniProtKB | ChEBI) | |||
Binding site | 276-283 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 361 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 402 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | mercury (II) reductase (NADP+) activity | |
Molecular Function | mercury ion binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | |
Biological Process | detoxification of mercury ion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMercuric reductase
- EC number
- Alternative names
Gene names
Encoded on
- Plasmid pIncAC-KP4898
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A237QZ82
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 135↔140 | Redox-active | |||
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length560
- Mass (Da)58,049
- Last updated2017-10-25 v1
- MD5 Checksum1EBE7EB577AB4B7F95E57E0B5FFDAED1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY882285 EMBL· GenBank· DDBJ | ASM79734.1 EMBL· GenBank· DDBJ | Genomic DNA |