A0A232EZU9 · A0A232EZU9_9HYME
- ProteinUbiquinone biosynthesis O-methyltransferase, mitochondrial
- Genecoq3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1451 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Catalytic activity
- a 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = a 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-homocysteine + H+
a 3,4-dihydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10930 + CHEBI:59789 = a 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10931 + CHEBI:57856 + CHEBI:15378
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 71 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 102 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 123 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 170 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Cellular Component | nucleus | |
Molecular Function | 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity | |
Molecular Function | 3-demethylubiquinol-n 3-O-methyltransferase activity | |
Molecular Function | exonuclease activity | |
Molecular Function | nucleic acid binding | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquinone biosynthesis O-methyltransferase, mitochondrial
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Proctotrupomorpha > Chalcidoidea > Pteromalidae > Pteromalinae > Trichomalopsis
Accessions
- Primary accessionA0A232EZU9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 524-565 | Basic and acidic residues | ||||
Sequence: PKFSDDEVTPVGDITKDKGSLEDTVSKILHDGKENKQLQEII | ||||||
Region | 524-926 | Disordered | ||||
Sequence: PKFSDDEVTPVGDITKDKGSLEDTVSKILHDGKENKQLQEIIEIDDDSDDKNQIDNEKIEKSDESSKHTREDTSKSKNKSSEKSSKEDSKHSKHKDDSKHSKSTEDSKHSKTKEDSKHSKSKDDVSKHSKSKDDDSKHSKSKDKDKSEDRKDKDKSEDRKDKDREKSKDKDKHKHSSKSSEKERSSSSSKDSKSRDKDKDKVKDSKSSKDSSHRSKKDSKSDKERSSSSKSSRDDKKESRDKSRHKSDDKSRHKSKSSSSDSKSKSSRSHKSSDRHSSHSSHKSNKSNEKNATETEDSDKNEDRSDKDEKCDSPEYEEFSPFYDEHLLETSDSDHDVEEECRKIFQEYEVPDTPKDITSKAPPKPESEGSEDVSKKRVAHPSAASSITKPVGPGQPIKRLPNP | ||||||
Compositional bias | 574-901 | Basic and acidic residues | ||||
Sequence: KNQIDNEKIEKSDESSKHTREDTSKSKNKSSEKSSKEDSKHSKHKDDSKHSKSTEDSKHSKTKEDSKHSKSKDDVSKHSKSKDDDSKHSKSKDKDKSEDRKDKDKSEDRKDKDREKSKDKDKHKHSSKSSEKERSSSSSKDSKSRDKDKDKVKDSKSSKDSSHRSKKDSKSDKERSSSSKSSRDDKKESRDKSRHKSDDKSRHKSKSSSSDSKSKSSRSHKSSDRHSSHSSHKSNKSNEKNATETEDSDKNEDRSDKDEKCDSPEYEEFSPFYDEHLLETSDSDHDVEEECRKIFQEYEVPDTPKDITSKAPPKPESEGSEDVSKKRV | ||||||
Region | 952-980 | Disordered | ||||
Sequence: SRAAETALQKKAAESSSAGSQNDSQVNGN | ||||||
Compositional bias | 961-980 | Polar residues | ||||
Sequence: KKAAESSSAGSQNDSQVNGN | ||||||
Domain | 1290-1449 | Exonuclease | ||||
Sequence: GVFALDCEMCYTTQGLELTRVTVINENKDVVYETLVKPANPIIDYNTRFSGISELDMKSVTTSLQNVQATLLSMFSSKTILIGHSLESDFKALKLLHNTVVDTSVMFPHKNGPPFKRALKTLCSEYLRKIIQNEIGGHDSKEDAVACMELVHWKVREEAK |
Sequence similarities
Belongs to the REXO1/REXO3 family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,451
- Mass (Da)162,668
- Last updated2017-10-25 v1
- Checksum406142EE76AC4E2D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 524-565 | Basic and acidic residues | ||||
Sequence: PKFSDDEVTPVGDITKDKGSLEDTVSKILHDGKENKQLQEII | ||||||
Compositional bias | 574-901 | Basic and acidic residues | ||||
Sequence: KNQIDNEKIEKSDESSKHTREDTSKSKNKSSEKSSKEDSKHSKHKDDSKHSKSTEDSKHSKTKEDSKHSKSKDDVSKHSKSKDDDSKHSKSKDKDKSEDRKDKDKSEDRKDKDREKSKDKDKHKHSSKSSEKERSSSSSKDSKSRDKDKDKVKDSKSSKDSSHRSKKDSKSDKERSSSSKSSRDDKKESRDKSRHKSDDKSRHKSKSSSSDSKSKSSRSHKSSDRHSSHSSHKSNKSNEKNATETEDSDKNEDRSDKDEKCDSPEYEEFSPFYDEHLLETSDSDHDVEEECRKIFQEYEVPDTPKDITSKAPPKPESEGSEDVSKKRV | ||||||
Compositional bias | 961-980 | Polar residues | ||||
Sequence: KKAAESSSAGSQNDSQVNGN |
Keywords
- Technical term