A0A232ERL3 · A0A232ERL3_9HYME
- ProteinAdenylate kinase
- GeneAk2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1151 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Catalytic activity
- AMP + ATP = 2 ADP
- GTP + AMP = GDP + ADP
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 29-34 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GSGKGT | ||||||
Binding site | 50 | AMP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 55 | AMP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 76-78 | AMP (UniProtKB | ChEBI) | ||||
Sequence: KLV | ||||||
Binding site | 104-107 | AMP (UniProtKB | ChEBI) | ||||
Sequence: GFPR | ||||||
Binding site | 111 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 157 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 166-167 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SY | ||||||
Binding site | 190 | AMP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 201 | AMP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 229 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | intraciliary transport particle A | |
Cellular Component | mitochondrial intermembrane space | |
Cellular Component | non-motile cilium | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | ATP metabolic process | |
Biological Process | intraciliary retrograde transport | |
Biological Process | non-motile cilium assembly | |
Biological Process | phosphorylation | |
Biological Process | protein localization to cilium |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Proctotrupomorpha > Chalcidoidea > Pteromalidae > Pteromalinae > Trichomalopsis
Accessions
- Primary accessionA0A232ERL3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Predominantly mitochondrial.
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for region, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-34 | Disordered | ||||
Sequence: MAPKTESLPKENVEEPSRGINAVLLGPPGSGKGT | ||||||
Region | 49-78 | NMPbind | ||||
Sequence: STGDMLRAEIQSGSALGAELKKVMDAGKLV | ||||||
Region | 156-193 | LID | ||||
Sequence: GRLIHPASGRSYHEEFAPPKVAMKDDITGEPLIKRSDD | ||||||
Domain | 157-192 | Adenylate kinase active site lid | ||||
Sequence: RLIHPASGRSYHEEFAPPKVAMKDDITGEPLIKRSD | ||||||
Repeat | 306-337 | WD | ||||
Sequence: LEGHNGHIQVVTWNEEHQKLTSSDQNGVIIVW | ||||||
Domain | 360-448 | Anaphase-promoting complex subunit 4-like WD40 | ||||
Sequence: MSWSSNGQKICIVYEDGAVIVGSVEGNRIWGKELKGLSLTAVQWSPDAKFLLFGTRNGEAHLYDDQGVFLTKLENISNGRVQGIVALDW |
Domain
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence similarities
Belongs to the adenylate kinase family. AK2 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,151
- Mass (Da)127,951
- Last updated2017-10-25 v1
- ChecksumFBCDF9417C217001
Keywords
- Technical term