A0A229G831 · A0A229G831_9ACTN

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site785-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site195uracil (UniProtKB | ChEBI)
Binding site200-202uracil (UniProtKB | ChEBI)
Binding site2015-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      B7755_50795

Organism names

  • Taxonomic identifier
  • Strain
    • NBS 14/10
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A229G831

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    22,776
  • Last updated
    2017-10-25 v1
  • Checksum
    C71ACEFBC6069D22
MRIHVVDHPLVAHKLTTLRDKRTDSPTFRRLADELVTLLAYEATRDVRTDQVDIETPVTATTGVRLSYPRPMVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRDEETLQASTYATRMPEDLSGRQVYVLDPMLATGGTLVAAIRELIARGADDVTALCLLAAPEGVETMERELAGAPVTVVTASVDERLNESGYIVPGLGDAGDRMYGTAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NCSM01000088
EMBL· GenBank· DDBJ
OXL20344.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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