A0A228Q176 · A0A228Q176_9BURK

  • Protein
    Shikimate dehydrogenase (NADP(+))
  • Gene
    aroE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15-17shikimate (UniProtKB | ChEBI)
Binding site65shikimate (UniProtKB | ChEBI)
Active site69Proton acceptor
Binding site81NADP+ (UniProtKB | ChEBI)
Binding site90shikimate (UniProtKB | ChEBI)
Binding site105shikimate (UniProtKB | ChEBI)
Binding site130-134NADP+ (UniProtKB | ChEBI)
Binding site219NADP+ (UniProtKB | ChEBI)
Binding site221shikimate (UniProtKB | ChEBI)
Binding site243NADP+ (UniProtKB | ChEBI)
Binding site250shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      CFB46_33500

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HI2761
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia

Accessions

  • Primary accession
    A0A228Q176

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-91Shikimate dehydrogenase substrate binding N-terminal
Domain121-197Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain243-269SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    28,862
  • Last updated
    2017-10-25 v1
  • Checksum
    35EF479AE5F2E361
MTDRYAVIGNPIGHTKSPLIHGLFAQETRQDIRYTAIEGPLEPAGAFAAAVRAFFDGGGKGINVTAPFKLDAFSMSDECSERAQLAGAANALKFDGGRILADNFDGIGLVRDIEANLNLPMAGKRVLVLGAGGAARGALLPFLEAGPAELVIANRDVDKACALATQVAGRGPLVAGSYADLARMGRFDLVVNATSASLTGDLPPVPPSVFSPTGTAYELAYGKRLTPFLRLAKNAGVHGIAEGVGMLVEQAAEAFAWWRGVRPATSSVIDRLAVPFD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NKFN01000009
EMBL· GenBank· DDBJ
OXJ21771.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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