A0A225CBG7 · A0A225CBG7_9MICO

Function

function

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycosyltransferase activity
Molecular Functionnicotinate phosphoribosyltransferase activity
Biological ProcessNAD salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nicotinate phosphoribosyltransferase
  • EC number

Gene names

    • ORF names
      B5P24_14370

Organism names

Accessions

  • Primary accession
    A0A225CBG7

Proteomes

Subcellular Location

PTM/Processing

Post-translational modification

Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-131Nicotinate phosphoribosyltransferase N-terminal

Sequence similarities

Belongs to the NAPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    46,142
  • Last updated
    2017-10-25 v1
  • Checksum
    4A30AE2FE5A5F8B2
MHQATSLLTDRYELTMLDAALKAGTHDRECVFECFARRLPSGRRFGVVAGTGRLLELIRDFRFGDAELEYLRSERVVGEEALAWLADYRFRGRITGYREGEVYFPGSPLLTVEAPFADGVILETLVLSVLNYDSAVASAAARMVQVAGARPLAEMGSRRTGERSAVAAARAAFIAGFSATSNLEAGRTWGVPTMGTAAHSFTLLHDTEEQAFRAQVDALGAGTTLLVDTYDVRQGVETAVRVAGTGLGAVRLDSGDLPVLVGEVRAQLDALGATGTRITVTNDLDEHGIAGLAASPVDSYGVGTSLVTGSGAPAAGMVFKLVAHREAGGRGEWVAVAKRSTGKQSRGGLKAALRRHDADGVATAELVTVGPHPDPRPGDRDLVVPLVEAGEPDPRWLGAEGTAAARAHHARVVRDLPAQAFRLRAGDPAIPTEEGSTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZMQ01000001
EMBL· GenBank· DDBJ
OQJ64097.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp