A0A225CA80 · A0A225CA80_9MICO

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site54carbamoyl phosphate (UniProtKB | ChEBI)
Binding site55carbamoyl phosphate (UniProtKB | ChEBI)
Binding site82L-aspartate (UniProtKB | ChEBI)
Binding site104carbamoyl phosphate (UniProtKB | ChEBI)
Binding site134carbamoyl phosphate (UniProtKB | ChEBI)
Binding site137carbamoyl phosphate (UniProtKB | ChEBI)
Binding site174L-aspartate (UniProtKB | ChEBI)
Binding site230L-aspartate (UniProtKB | ChEBI)
Binding site271carbamoyl phosphate (UniProtKB | ChEBI)
Binding site272carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      B5P24_11540

Organism names

Accessions

  • Primary accession
    A0A225CA80

Proteomes

Subcellular Location

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-146Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain161-309Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    34,092
  • Last updated
    2017-10-25 v1
  • Checksum
    75A2BFADDBAD26E8
MRHLLSTRDLSRDEAVHILDVAEDMADVGTREIKKTPALRGRTVVNLFFEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTAQTLQAMGADGVVVRHPSSGAPHTLAGSGWIDAGIVNAGDGTHEHPTQALLDAFTIRRRLHGSAARGKGLDGTRVVIVGDVLHSRVARSNAWLLTTLGAEVTLVAPPTLVPVGVGSWPVQVRYDLDAALVEGKPDAVMMLRIQAERMRAAFFPNPREYARIWGLDDARLALLGPDTIVMHPGPMNRGLEISAAAADSERSTVREQVANGVSVRMAVLYLLLSGDGKADR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZMQ01000001
EMBL· GenBank· DDBJ
OQJ63578.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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