A0A225C413 · A0A225C413_9MICO

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site41-48ATP (UniProtKB | ChEBI)
Active site48Proton donor
Binding site72(R)-pantoate (UniProtKB | ChEBI)
Binding site72beta-alanine (UniProtKB | ChEBI)
Binding site159-162ATP (UniProtKB | ChEBI)
Binding site165(R)-pantoate (UniProtKB | ChEBI)
Binding site188ATP (UniProtKB | ChEBI)
Binding site196-199ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      B5P24_01360

Organism names

Accessions

  • Primary accession
    A0A225C413

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    292
  • Mass (Da)
    30,752
  • Last updated
    2017-10-25 v1
  • Checksum
    CCA56DA8FCE8AC1D
MTIPAPTVVTGIAELRALVRAHRAERAAAGEEAVVVLVPTMGALHEGHLAHARHARAAGSLVVVSVFVNPLQFGAGEDLDAYPRTLDADVEALAATGVDLVFAPSAAEMYPDGPARIRVSGGSVALALEGRSRPGHFDGMLTVVAKLLHIVAPDVATFGRKDAQQLHLVRRMVRDLDLPVRIEELETVREPDGLALSSRNRYLDERERRAARVIPAALEAAQSAGSRGIDAVIAAAQSVVMGEPAVALDYFQVVDPSTFESVDDGFTGAALAVIAARVGTTRLIDNDTVVIA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZMQ01000001
EMBL· GenBank· DDBJ
OQJ61777.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp