A0A225C3U8 · A0A225C3U8_9MICO

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site221-224CoA (UniProtKB | ChEBI)
Binding site341CoA (UniProtKB | ChEBI)
Binding site417-419ATP (UniProtKB | ChEBI)
Binding site441-446ATP (UniProtKB | ChEBI)
Binding site530ATP (UniProtKB | ChEBI)
Binding site545ATP (UniProtKB | ChEBI)
Binding site553CoA (UniProtKB | ChEBI)
Binding site556ATP (UniProtKB | ChEBI)
Binding site567Mg2+ (UniProtKB | ChEBI)
Binding site569Mg2+ (UniProtKB | ChEBI)
Binding site572Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acsA
    • ORF names
      B5P24_01015

Organism names

Accessions

  • Primary accession
    A0A225C3U8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue642N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-24Polar residues
Region1-46Disordered
Domain58-111Acetyl-coenzyme A synthetase N-terminal
Domain117-508AMP-dependent synthetase/ligase
Domain561-642AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    679
  • Mass (Da)
    73,522
  • Last updated
    2017-10-25 v1
  • Checksum
    465A50A8B0224A72
MTMSTNPESTEPGTPTAAPREQDEEGTTSLSRPPEAPEPGQVHPPTEAFRATRVADESLAEAAAADRLGFWGDRARELVTWETPFDTVLDWSDAPVARWFPEGRLNVAYNCLDRHVLAGNGDRVALHWEGEPGDTRDLTYADLTAEVKRAANALLDLGVTAGDRVAIYLPMIPEAVVAMLAVARIGAVHSVVFGGFSAESLRARIDDAAARVVITADGGWRKGKVFPLKPAVDAALVGSAGSVEHVLVVRRGENEVEWDASRDIWWHERVAAADPEHEAEAFEAEHPLFILYTSGTTGKPKGILHTSGGYLTQAAYTHRNVFDLHPETDVYWCTADVGWITGHSYVVYGPLANGATQVVYEGTPDTPEPGRWWDIVEKHGVTILYAAPTAIRSFMKTGREIPDARDLSSIRLLGSVGEPINPEAWRWYRDVIGGGDVPVVDTWWQTETGGIMISPLPGITATKPGSAQTPLPGISIAVVDDAGQPVGPGESGLLVVTEPWPGMLRGIWGDPERYRETYWDRFGDRYFAGDGARLDEDGDVWLLGRVDDVMNVSGHRLSTAEIESSLVGHPYVAEAAVVGASDEATGQAVVAFVILRTAEASAFGDEDPNEVLRAHVAEQIGAIAKPRRVFVVQELPKTRSGKIMRRLLRDVAEGRAVGDTTTLADTQVMQVITERMSAG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-24Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZMQ01000001
EMBL· GenBank· DDBJ
OQJ61717.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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