A0A224YV36 · A0A224YV36_9ACAR

  • Protein
    Carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site264Nucleophile
Active site348
Active site350

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Rhipicephalinae > Rhipicephalus > Rhipicephalus

Accessions

  • Primary accession
    A0A224YV36

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain529-721ATP-grasp
Domain1066-1257ATP-grasp
Domain1322-1491MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,279
  • Mass (Da)
    249,406
  • Last updated
    2017-10-25 v1
  • Checksum
    C14449BB27A4D79E
METALKRRPAQLILEDGTTYAGVSFGNPRCISGEVVFQTGMVGYVESLTDPSYCRQILVLTYPLIGNYGVPSAEEKDSHGIPVNFESHKIWAAGLVVGECVDKYSHWSARRSLSDWLDASAVPGISGIDTRELTKKIRERGTMLGKIVVEGMENTPLKFENPNLLNLVKEVSLKAPKVYNKGGTPSITVVDCGMKYNQLRCLLSRGACVTVVPWDHPVNPKDCDGLFVSNGPGDPTQCTATIKMLQTFLGCNDPAKLKPVFGICLGHQLVCRAIGAATYKMKYGNRGHNQPCLFGSSGRCCITTQNHGYAVDASTLPSDWSPLFTNANDRTNEGVVHKKLPFFSVQFHPEHMAGPADLEFLFDVFIESVKDSVASKAYTPIEDRISAKFAALAPPPVLASKRPRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEKIQTILINPNIATVQTSPGLADKVYFLPITPYYVGEVIKSERPDGVLLTFGGQTALNCGVELQKNGTLDRYGVAVLGTPIESIINSEDRKLFAELVAEIGEQVVPNCAVYSVEEALTAAEKLGFPILVRGAFCLGGLGSGFAHNQDELRTLVAQALVRSSQVLLDRSLKGWKEVEYEVVRDAFDNCITVCNMENLDPLGIHTGESIVVAPSQTLTNEEYNRLRTTAIRVVRRLGIVGECNVQYALSPHSFEYYIVEVNARLSRSSALASKATGYPLAYIAAKLALGISLPSLRNTVTCQTTACFEPSLDYCVVKIPRWDLGKFPHVSNKIGSSMKSVGEVMSIGRSFEEAFQKAIRMVEEHVSGLDPYLKPVSDRELACPTDKRMFHLASAIKAGYTVKQLNELTQIDPWFLSKIINIIEYHTFLEGLHSKPALLTFDVLLRAKQLGFSDKQIGQCVGSTELVVRKTRQELGVVPRVKQVDTVAAEWPAATNYLYLTYNAKEDDLQFEPQSAIMVLGSGVYRIGSSVEFDWCAVSCVQELRKLGKATIMVNCNPETVSTDYDMCDRLYFDEISFETVMDIYCMEQPEGIILNMGGQLPNNIAMDLYRQKARILGTSPESIDCAENRFKFSRMLDSIGISQPQWKELTNLENIKSFCEEAGYPCLVRPSYVLSGAAMNVAYSHRDLEGYLNEASAVSKEHPVVISKFICEAKEIDVDAVAKDGVLVAMAVSEHVENAGVHSGDATLVTPPQDLNSETLAKIRSICQAIGEALIVSGPYNMQLIAKDNQLKVIECNLRVSRSFPFVSKTLNCDFVALATQVILGLPVEARDVTFGVARVGVKVPQFSYSRLAGADIRLGVEMASTGEVACFGENRYEAYLKALLSTGFCIPEKKIFLSIGSYKHKAEFLPSVRTLEKMGFQLYGSLGTSDFYMEHGIKIEPMTWPFHDHDVDEDTVNGGSDGGSQCVSQQAQLSIADFLEQKEFDLVVNLPMCSSGARRISTMFTQGYRTRRMAVDYAVPLVTDVKCAKLLVEALRLIRKAPPVKTHIDCLTSRNIVRLPGLIDVHVHMREPGATEKEDYASGTAAALAGGFTTVCAMPNTRPPLCDAESLAVCQMAARAGARCDYAFFAGANQTNAESVVSLAPSVVGLKMYLNDTYGPLCMDTVSDWLKHFEKWPRHMPLCCHAEGPRTAAVILLASLQQRPVHICHVAREEEISIIKAAKAQGHAVTCEVTPHHLFLTVDDIDRLGPNVAKVKPPLMTAKDQKALWDNIDIIDCIATDHAPHTYAEKTQPNAPPGFPGLETSLPLMLTAVAEGKITMAALLKKMYDNPRRIFNLPVQHDTYIEVDLDEEWTIPEAPTYSRAGWTPFAGRKVRGQVRRVVIRGEVVFVDGQVLVEPGFGQDVMAIPELERSASMSSLTHAEKGSPGISETFSVAGATVGKRGHWRNSVKSLTTEMYNKMFQELGLPDKLMVPTSVAAAAVSSSDEAASGSRLGTASAPAAVSSLRSISPLMSASGSGAMTAAGTVSLSWSLPDIPNALHGRHILTADMFSKDQMHSLFNLAHAFSVFVQKDRPLDHVLKGKVMASVFYEVSTRTSCSFAAAMQRLGGSVIHMDQATSSTQKGETLEDTITVMSNYSDVVVLRHPQPGAVMRASKHCRKPVINAGDGIGEHPTQALLDVYTIREEIGTVNNLTVTLVGDLKHGRTVHSLARLLTHYNVQLRYVAPANLGMPQSVRDVVAAQGVIQEDIESLEAALPDTDVLYMTRIQKERFSSVEEYEKACGLYVVTPQLMTKAKKRMIVMHPLPRVFEISPDFDTDPRAAYFRQAEAGMYVRMALLAMVLGRV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GFPF01006546
EMBL· GenBank· DDBJ
MAA17692.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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